-
Article
Open AccessImpact of methodological choices in comparative effectiveness studies: application in natalizumab versus fingolimod comparison among patients with multiple sclerosis
Natalizumab and fingolimod are used as high-efficacy treatments in relapsing–remitting multiple sclerosis. Several observational studies comparing these two drugs have shown variable results, using different m...
-
Article
Has sclerostin a true endocrine metabolic action complementary to osteocalcin in older men?
The reported association between sclerostin and diabetes mellitus or abdominal fat may be biased by body size and bone mass. In older men, the association between serum sclerostin levels and metabolic syndrome...
-
Article
Erratum to: Visceral obesity stimulates anaphase bridge formation and spindle assembly checkpoint dysregulation in radioresistant oesophageal adenocarcinoma
-
Article
Visceral obesity stimulates anaphase bridge formation and spindle assembly checkpoint dysregulation in radioresistant oesophageal adenocarcinoma
Oesophageal adenocarcinoma is an exemplar model of obesity-associated cancer. Locally advanced disease is treated with neoadjuvant chemoradiotherapy, and survival rates are highest in patients demonstrating a ...
-
Article
Open AccessSpatial accessibility to physical activity facilities and to food outlets and overweight in French youth
Some characteristics of the built environment have been associated with obesity in youth. Our aim was to determine whether individual and environmental socio-economic characteristics modulate the relation betw...
-
Article
Leisure-time physical activity and sedentary behavior clusters and their associations with overweight in middle-aged French adults
To identify leisure-time physical activity (LTPA) and sedentary behavior patterns, as well as to investigate their relationships with overweight.
-
Article
Interferometric measurement of ionization in a grassfire
Grassfire plumes are weakly ionized gas. The ionization in the fire plume is due to thermal and chemi-ionization of incumbent species, which may include graphitic carbon, alkalis and thermally excited radicals...
-
Article
Cyclo-oxygenase inhibition attenuates endotoxin-induced primary tumour growth and metastasis
COX-2 inhibitors may be of benefit in patients at risk of metastatic disease, particularly if they are also at risk of endotoxaemia.
-
Article
Intracavernosal alprostadil is effective for the treatment of erectile dysfunction in diabetic men
The efficacy and safety of intracavernosal alprostadil was evaluated for the treatment of erectile dysfunction in men with type I or type II diabetes mellitus. This was an open-label, flexible dose-escalating ...
-
Article
Analysis of a lipoxygenase pseudogene in Pisum
Lipoxygenase (LOX) enzymes play important roles in plant biology, and in the quality of plant-derived foods, through the production of fatty acid hydroperoxides that are metabolized either to jasmonate, or to...
-
Chapter
Genetic manipulation of lipoxygenases for the agrifood industry
Lipoxygenases (LOX) are a group of non-haem iron-containing enzymes that are widely distributed within Nature and can be found in algae, fungi, animals and plants. In animals they are recognized as catalyzing ...
-
Chapter and Conference Paper
Production of Pea Seed Lipoxygenases in Escherichia coli
The two major forms of lipoxygenase from pea seeds (LOX 2 and 3) have been cloned and expressed as soluble, active, non-fusion proteins in Escherichia coli. Unambiguous measurements to date comparing the homogene...
-
Chapter and Conference Paper
The Organization and Expression of Pea Seed Lipoxygenase Genes; Implications for Off-flavor Production in Frozen Peas and Pea Protein Isolates
A pea line that lacks seed lipoxygenase-2 was used to produce germplasm that may be commercially useful in the production of frozen peas and/or pea protein isolates because it produces less n-hexanal, an off-flav...
-
Article
Pisum lipoxygenase genes
The copy number, genomic arrangement and linkage relationships of two classes of lipoxygenase gene have been investigated in Pisum(pea) lines. Each of the two classes contained two to three members in P. sativum ...
-
Article
Processing Pisum sativum seed storage protein precursors in vitro
The profile of polypeptides separated by SDS-PAGE from seed of major crop species such as pea (Pisum sativum) is complex, resulting from cleavage (processing) of precursors expressed from multiple copies of genes...
-
Article
Another class of vicilin gene in Pisum
We describe a novel class of vicilin gene in Pisum corresponding to a precursor polypeptide of Mr 68000. The mRNA corresponding to this polypeptide accumulates during seed development in a pattern similar to that...
-
Article
Lipoxygenase heterogeneity in Pisum sativum
Antibodies raised against two pea (Pisum sativum L. cv. Birte) seed lipoxygenases have been used to analyze lipoxygenase heterogeneity in seeds and in other organs. At least seven different polypeptides were iden...
-
Article
Inheritance and map** of seed lipoxygenase polypeptides in Pisum
Analysis of crosses of Pisum lines showing variation in the apparent molecular weight of seed lipoxygenase polypeptides indicates that the genes encoding the two major pea seed lipoxygenase polypeptides are close...
-
Chapter and Conference Paper
Inflammation and Angiogenesis
Acute inflammation (i.e., caused by a superficial infection) is generally associated only with dilated vessels in the microcirculation of the skin. In chronic inflammation, dilated blood vessels are also accom...
-
Article
Legumin heterogeneity inPisum
Analyses of heterogeneity in legumin subunit patterns, legumin precursor polypeptides, and restriction fragments containing legumin genes have shown thatPisum (pea) genotypes vary in the extent of gene and polype...
