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  1. Article

    Open Access

    Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function

    Prolonged intake of excessive amounts of ethanol is known to have adverse effects on the central nervous system (CNS). Here we investigated the effects of acute and chronic ethanol exposure and withdrawal from...

    Iben Lundgaard, Wei Wang, Allison Eberhardt, Hanna Sophia Vinitsky… in Scientific Reports (2018)

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  2. No Access

    Article

    Cortical spreading depression causes and coincides with tissue hypoxia

    Cortical spreading depression (CSD) is a self-propagating wave of cellular depolarization that has been implicated in migraine and in progressive neuronal injury after stroke and head trauma. Using two-photon ...

    Takahiro Takano, Guo-Feng Tian, Weiguo Peng, Nanhong Lou… in Nature Neuroscience (2007)

  3. No Access

    Article

    Angiogenic inhibition reduces germinal matrix hemorrhage

    The germinal matrix of premature infants is selectively vulnerable to hemorrhage within the first 48 h of life. To assess the role of vascular immaturity in germinal matrix hemorrhage (GMH), we evaluated germi...

    Praveen Ballabh, Hongmin Xu, Furong Hu, Alex Braun, Kira Smith… in Nature Medicine (2007)

  4. No Access

    Article

    Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo

    Although astrocytes are the most abundant cell type in the brain, evidence for their activation during physiological sensory activity is lacking. Here we show that whisker stimulation evokes increases in astro...

    **aohai Wang, Nanhong Lou, Qiwu Xu, Guo-Feng Tian, Wei Guo Peng… in Nature Neuroscience (2006)

  5. No Access

    Article

    Astrocyte-mediated control of cerebral blood flow

    Local increase in blood flow during neural activity forms the basis for functional brain imaging, but its mechanism remains poorly defined. Here we show that cortical astrocytes in vivo possess a powerful mechani...

    Takahiro Takano, Guo-Feng Tian, Weiguo Peng, Nanhong Lou… in Nature Neuroscience (2006)

  6. No Access

    Article

    An astrocytic basis of epilepsy

    Hypersynchronous neuronal firing is a hallmark of epilepsy, but the mechanisms underlying simultaneous activation of multiple neurons remains unknown. Epileptic discharges are in part initiated by a local depo...

    Guo-Feng Tian, Hooman Azmi, Takahiro Takano, Qiwu Xu, Weiguo Peng… in Nature Medicine (2005)