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Article
Ferroptosis: a critical mechanism of N6-methyladenosine modification involved in carcinogenesis and tumor progression
Ferroptosis is an iron-dependent regulatory cell necrosis induced by iron overload and lipid peroxidation. It occurs when multiple redox-active enzymes are ectopically expressed or show abnormal function. Henc...
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Article
Open AccessEfficacy and safety of baricitinib for the treatment of hospitalized adults with COVID-19: a systematic review and meta-analysis
Several clinical trials have evaluated the efficacy and safety of baricitinib in COVID-19 patients. Recently, there have been reports on critical patients, which are different from previous research results. T...
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Article
Open AccessWD repeat domain 82 (Wdr82) facilitates mouse iPSCs generation by interfering mitochondrial oxidative phosphorylation and glycolysis
Abundantly expressed factors in the oocyte cytoplasm can remarkably reprogram terminally differentiated germ cells or somatic cells into totipotent state within a short time. However, the mechanism of the diff...
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Article
Open AccessImplantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells
Spatially ordered embryo-like structures self-assembled from blastocyst-derived stem cells can be generated to mimic embryogenesis in vitro. However, the assembly system and developmental potential of such str...
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Chapter and Conference Paper
Virtual Force Senor Based on PSO-BP Neural Network for Legged Robots in Planetary Exploration
The foot force of the legged robot plays a decisive role in the balance of the fuselage. Especially when walking on the irregular road surface and the less rigid road surface, the change of the foot end suppor...
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Chapter and Conference Paper
Virtual-Sensor-Based Planetary Soil Classification with Legged Robots
The estimation of soil properties is crucial for legged robots during planetary exploration missions. A virtual-sensor-based soil classification approach for legged robots is proposed in this paper. Instead of...
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Article
The Arabidopsis nucleoporin NUP1 is essential for megasporogenesis and early stages of pollen development
Loss-of-function of nucleoporin NUP1 in Arabidopsis causes defect in both male and female gametogenesis. Its ovules are arrested during meiosis, and its pollen grains are aborted at mitosis I.
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Article
Open AccessPluripotent stem cells secrete Activin A to improve their epiblast competency after injection into recipient embryos
It is not fully clear why there is a higher contribution of pluripotent stem cells (PSCs) to the chimera produced by injection of PSCs into 4-cell or 8-cell stage embryos compared with blastocyst injection. He...
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Article
Open AccessLong non-coding RNAs involved in the regulatory network during porcine pre-implantation embryonic development and iPSC induction
Long non-coding RNAs (lncRNA) play a key role in the orchestration of transcriptional regulation during development and many other cellular processes. The importance of the regulatory co-expression network was...
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Article
Open AccessDouble knockout of Bax and Bak from kidney proximal tubules reduces unilateral urethral obstruction associated apoptosis and renal interstitial fibrosis
Interstitial fibrosis, a common pathological feature of chronic kidney diseases, is often associated with apoptosis in renal tissues. To determine the associated apoptotic pathway and its role in renal interst...
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Article
Open AccessInduction of Germ Cell-like Cells from Porcine Induced Pluripotent Stem Cells
The ability to generate germ cells from pluripotent stem cells (PSCs) is valuable for human regenerative medicine and animal breeding. Germ cell-like cells (GCLCs) have been differentiated from mouse and human...
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Article
Open AccessImprovement in Mouse iPSC Induction by Rab32 Reveals the Importance of Lipid Metabolism during Reprogramming
Induced pluripotent stem cells (iPSCs) have variable expression levels of a series of genes that affect their pluripotent potential, but the regulatory mechanisms controlling reprogramming remain unclear. By t...
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Chapter
Apoptosis in Acute Kidney Injury
Acute kidney injury (AKI), also called acute renal failure, is a major kidney disease associated with high mortality. Under the disease condition, renal tubular cells are reversibly or irreversibly injured, un...
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Article
Imaging bacteriorhodopsinlike molecules of claretmembranes from Tibet halobacteria xz515 by atomic force microscope
HalobacteriaH.sp.xz 515 was isolated from a salt lake in Tibet. Although proton release-and-uptake across claret membrane is in reverse order compared to bacteriorhodopsin in purple membrane fromHalobacterium Sal...
