22 Result(s)

Article

Exploring the dynamic three-dimensional chromatin architecture and transcriptional landscape in goose liver tissues underlying metabolic adaptations induced by a high-fat diet

Goose, descendants of migratory ancestors, have undergone extensive selective breeding, resulting in their remarkable ability to accumulate fat in the liver and exhibit a high tolerance for significant energy ...

Guangliang Gao, Rui Liu, Silu Hu, Mengnan He… in Journal of Animal Science and Biotechnology (2024)

Article

The relationship between complement C1q and coronary plaque vulnerability based on optical coherence tomography analysis

To determine the association between complement C1q and vulnerable plaque morphology among coronary artery disease (CAD) patients. We conducted a retrospective observational study of 221 CAD patients admitted ...

Yuan Wang, Jiawei Zheng, Qing Li, Yao Ma, Chang Liu, Jie Deng… in Scientific Reports (2024)

Article

Generation of three-dimensional meat-like tissue from stable pig epiblast stem cells

Cultured meat production has emerged as a breakthrough technology for the global food industry with the potential to reduce challenges associated with environmental sustainability, global public health, animal...

Gaoxiang Zhu, Dengfeng Gao, Linzi Li, Yixuan Yao, Yingjie Wang… in Nature Communications (2023)

Article

Development of a novel tool: a nomogram for predicting in-hospital mortality of patients in intensive care unit after percutaneous coronary intervention

Increased risk of in-hospital mortality is critical to guide medical decisions and it played a central role in intensive care unit (ICU) with high risk of in-hospital mortality after primary percutaneous coron...

Miao Yuan, Bin Cheng Ren, Yu Wang, Fuxian Ren, Dengfeng Gao in BMC Anesthesiology (2023)

Article

Generation and characterization of stable pig pregastrulation epiblast stem cell lines

Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad prospects for human therapeutic model development and livestock breeding. Despite ongoing attempts since the 1990s, ...

Minglei Zhi, **ying Zhang, Qianzi Tang, Dawei Yu, Shuai Gao, Dengfeng Gao… in Cell Research (2022)

Article

METTL3-mediated mRNA N⁶-methyladenosine is required for oocyte and follicle development in mice

Proper follicle development is very important for the production of mature oocytes, which is essential for the maintenance of female fertility. This complex biological process requires precise gene regulation....

Haiyuan Mu, Ting Zhang, Ying Yang, Danru Zhang, Jie Gao, Junhong Li… in Cell Death & Disease (2021)

Article

Corticosteroids in diabetes patients infected with COVID-19

Fuxue Deng, Dengfeng Gao, … in Irish Journal of Medical Science (1971 -) (2021)

Article

IRF-1 expressed in the inner cell mass of the porcine early blastocyst enhances the pluripotency of induced pluripotent stem cells

Despite years of research, porcine-induced pluripotent stem cells (piPSCs) with germline chimeric capacity have not been established. Furthermore, the key transcription factors (TFs) defining the naïve state i...

Bingbo Shi, Dengfeng Gao, Liang Zhong, Minglei Zhi… in Stem Cell Research & Therapy (2020)

Article

A cytokine screen using CRISPR-Cas9 knock-in reporter pig iPS cells reveals that Activin A regulates NANOG

NANOG functions as the gateway for the generation of pluripotent stem cells (PSCs) in mice and humans. NANOG is a transcription factor highly expressed in pig pre-implantation embryos, indicating that it is a con...

Junjun Xu, Zheng Zheng, Xuguang Du, Bingbo Shi… in Stem Cell Research & Therapy (2020)

Article

Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system

Pigs have emerged as one of the most popular large animal models in biomedical research, which in many cases is considered as a superior choice over rodent models. In addition, transplantation studies using pi...

Junjun Xu, Leqian Yu, Jianxiong Guo, **zhu **ang… in Stem Cell Research & Therapy (2019)

Article

Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells

Spatially ordered embryo-like structures self-assembled from blastocyst-derived stem cells can be generated to mimic embryogenesis in vitro. However, the assembly system and developmental potential of such str...

Shaopeng Zhang, Tianzhi Chen, Naixin Chen, Dengfeng Gao… in Nature Communications (2019)

Article

Integrated analysis of microRNA and mRNA expression profiles in rats with selenium deficiency and identification of associated miRNA-mRNA network

Selenium deficiency is closely related with various type of cardiovascular disease. However, the miRNA-mRNA regulatory network in Selenium deficiency related cardiac change remains to be understand. In the pre...

Yan**g Feng, Yunjie **ng, Zhongwei Liu, Guang Yang, **aolin Niu… in Scientific Reports (2018)