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  1. No Access

    Article

    Gut microbial fatty acid isomerization modulates intraepithelial T cells

    The human gut microbiome constantly converts natural products derived from the host and diet into numerous bioactive metabolites1–3. Dietary fats are essential micronutrients that undergo lipolysis to release fre...

    **nyang Song, Haohao Zhang, Yanbo Zhang, Byoungsook Goh, Bin Bao, Suelen S. Mello… in Nature (2023)

  2. No Access

    Protocol

    In Vitro Reconstitution of Pseudouridylation Catalyzed by Human Box H/ACA Ribonucleoprotein Particles

    Pseudouridine (Ψ) is the most common chemical modification in RNA. In eukaryotes and archaea, pseudouridine synthases, mainly guided by box H/ACA snoRNAs, convert uridine to Ψ. Ψ stabilizes RNA structure and a...

    Hironori Adachi, Jonathan L. Chen, Qiangzong Yin… in RNA-Protein Complexes and Interactions (2023)

  3. No Access

    Article

    Dynamic epigenomic landscapes during early lineage specification in mouse embryos

    In mammals, all somatic development originates from lineage segregation in early embryos. However, the dynamics of transcriptomes and epigenomes acting in concert with initial cell fate commitment remains poor...

    Yu Zhang, Yunlong **ang, Qiangzong Yin, Zhenhai Du, Xu Peng, Qiujun Wang… in Nature Genetics (2018)

  4. Article

    Open Access

    DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD

    Epigenetics changes have been shown to be affected by cigarette smoking. Cigarette smoke (CS)-mediated DNA methylation can potentially affect several cellular and pathophysiological processes, acute exacerbati...

    Isaac K. Sundar, Qiangzong Yin, Brian S. Baier, Li Yan… in Clinical Epigenetics (2017)

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  5. No Access

    Article

    Allelic reprogramming of the histone modification H3K4me3 in early mammalian development

    Three papers in this issue of Nature use highly sensitive ChIP–seq assays to describe the dynamic patterns of histone modifications during early mouse embryogenesis, showing that oocytes have a distinctive epigen...

    Bingjie Zhang, Hui Zheng, Bo Huang, Wenzhi Li, Yunlong **ang, Xu Peng, Jia Ming… in Nature (2016)

  6. No Access

    Article

    The landscape of accessible chromatin in mammalian preimplantation embryos

    In mammals, extensive chromatin reorganization is essential for reprogramming terminally committed gametes to a totipotent state during preimplantation development. However, the global chromatin landscape and ...

    **gyi Wu, Bo Huang, He Chen, Qiangzong Yin, Yang Liu, Yunlong **ang… in Nature (2016)

  7. No Access

    Article

    Bisulfite-free, base-resolution analysis of 5-formylcytosine at the genome scale

    Chemical modification of 5fC allows its enrichment and genome-wide profiling at single-nucleotide resolution.

    Bo **a, Dali Han, **ngyu Lu, Zhaozhu Sun, Ankun Zhou, Qiangzong Yin… in Nature Methods (2015)