48 Result(s)

Article

Synthetic Analogs of Green Tea Polyphenols as Proteasome Inhibitors

Animal, epidemiological and clinical studies have demonstrated the anti-tumor activity of pharmacological proteasome inhibitors and the cancer-preventive effects of green tea consumption. Previously, one of ou...

David M. Smith, Zhigang Wang, Aslamuzzaman Kazi, Lian-hai Li… in Molecular Medicine (2002)

Protocol

Cell Cycle and Drug Sensitivity

Induction of tumor cell death by chemotherapeutic modalities often occurs in a cell cycle-dependent manner. It has also been observed that several regulatory proteins involved in tumor chemosensitivity and apo...

Aslamuzzaman Kazi, Q. ** Dou in Chemosensitivity: Volume II (2005)

Article

Molecular cytogenetic analyses of hexaploid lines spontaneously appearing in octoploid Triticale

Genome characterization of 14 hexaploid lines that spontaneously appeared in octoploid Triticales was carried out by sequential genomic in situ hybridization and fluorescence in situ hybridization, high molecu...

Q. W. Dou, H. Tanaka, N. Nakata, H. Tsujimoto in Theoretical and Applied Genetics (2006)

Article

The challenge of develo** green tea polyphenols as therapeutic agents

The health benefits of green tea and its main constituent (-)-epigallocatechin gallate [(-)-EGCG] have been widely supported by results from epidemiological, cell culture, animal and clinical studies. On the o...

C. Huo, S. B. Wan, W. H. Lam, L. Li, Z. Wang, K. R. Landis-Piwowar… in Inflammopharmacology (2008)

Article

New Difluoro Knoevenagel Condensates of Curcumin, Their Schiff Bases and Copper Complexes as Proteasome Inhibitors and Apoptosis Inducers in Cancer Cells

Emerging evidence clearly suggests the potential chemopreventive and anti-tumor activity of a well known “natural agent” curcumin. However, studies have shown that curcumin is not readily bioavailable, and thu...

Subhash Padhye, Huanjie Yang, Abeda Jamadar, Qiuzhi Cindy Cui… in Pharmaceutical Research (2009)

Article

Fluorocurcumins as Cyclooxygenase-2 Inhibitor: Molecular Docking, Pharmacokinetics and Tissue Distribution in Mice

The purpose of the current study was to assess the effect of newly synthesized Curcumin analogs on COX-2 protein by molecular docking studies and by assessments of the effect of one such analog (CDF) on nuclea...

Subhash Padhye, Sanjeev Banerjee, Deepak Chavan… in Pharmaceutical Research (2009)

Chapter and Conference Paper

Abrasion-Resistant Technology and its Prospect for CFB Boilers

In recent years, CFB boilers (CFBB) have been widely used in the commercial power plants due to its environmental benefits, high combustion efficiency, wide coal flexibility, and some other advantages. At the ...

H. Zheng, Y. J. Li, L. J. Wang, S. H. Liu… in Proceedings of the 20th International Conf… (2010)

Article

Tumor cellular proteasome inhibition and growth suppression by 8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into cells

We have previously reported that when mixed with copper, 8-hydroxyquinoline (8-OHQ) and its analog clioquinol (CQ) inhibited the proteasomal activity and proliferation in cultured human cancer cells. CQ treatm...

Shumei Zhai, Lei Yang, Qiuzhi Cindy Cui… in JBIC Journal of Biological Inorganic Chemi… (2010)

Article

Targeted proteasome inhibition by Velcade induces apoptosis in human mesothelioma and breast cancer cell lines

Thoracic malignancies and human breast cancer (HBC) continue to be aggressive solid tumors that are poor responders to the existing conventional standard chemotherapeutic approaches. Malignant pleural mesothel...

Ying Wang, Arun K. Rishi… in Cancer Chemotherapy and Pharmacology (2010)

Article

Molecular characterization and phylogenetic analysis of a yak (Bos grunniens) κ-casein cDNA from lactating mammary gland

κ-Casein is one of the major proteins in the milk of mammals. It plays an important role in determining the size and specific function of milk micelles. We have previously identified and characterized a geneti...

W. L. Bai, R. H. Yin, Q. L. Dou, W. Q. Jiang, S. J. Zhao… in Molecular Biology Reports (2011)

Chapter

Nutritional Compounds as Chemopreventive Agents by Proteasome Inhibition

Nutritional phytochemicals, distributed throughout the plant kingdom, possess anticancer activities associated with their consumption. This chapter will focus on the cellular activities of phytochemicals, thei...

Kristin Landis-Piwowar, Elizabeth Smerczak, Jian Zuo… in Nutrition, Diet and Cancer (2012)

Article

Transcriptional activation of breast cancer-associated gene 2 by estrogen receptor

RNF115, or Breast Cancer-Associated Gene 2 (BCA2), encodes a RING-finger ubiquitin E3 ligase, expression of which was associated with estrogen receptor (ER)-positive status in human breast tumors. Although the...

Fathima R. Kona, Karri Stark, Luke Bisoski… in Breast Cancer Research and Treatment (2012)

Article

Association of Metals and Proteasome Activity in Erythrocytes of Prostate Cancer Patients and Controls

Information is lacking on the effects toxic environmental metals may have on the 26S proteasome. The proteasome is a primary vehicle for selective degradation of damaged proteins in a cell and due to its role ...

Christine Neslund-Dudas, Bharati Mitra… in Biological Trace Element Research (2012)

Article

1,10-Phenanthroline promotes copper complexes into tumor cells and induces apoptosis by inhibiting the proteasome activity

Indole-3-acetic acid and indole-3-propionic acid, two potent natural plant growth hormones, have attracted attention as promising prodrugs in cancer therapy. Copper is known to be a cofactor essential for tumo...

Zhen Zhang, Caifeng Bi, Sara M. Schmitt… in JBIC Journal of Biological Inorganic Chemi… (2012)

Reference Work Entry In depth

Gallium(III) Complexes, Inhibition of Proteasome Activity

Michael Frezza, Sara Schmitt, Dajena Tomco, Dr. Di Chen… in Encyclopedia of Metalloproteins (2013)