5 Result(s)
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Article
Distinct Mu, Delta, and Kappa Opioid Receptor Mechanisms Underlie Low Sociability and Depressive-Like Behaviors During Heroin Abstinence
Addiction is a chronic disorder involving recurring intoxication, withdrawal, and craving episodes. Esca** this vicious cycle requires maintenance of abstinence for extended periods of time and is a true cha...
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Article
Open AccessGlobal long non-coding RNA expression in the rostral anterior cingulate cortex of depressed suicides
Long non-coding RNAs (lncRNAs) are an emerging class of regulatory RNA that may be implicated in psychiatric disorders. Here we performed RNA-sequencing in the rostral anterior cingulate cortex of 26 depressed...
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Article
Evidence of decreased gap junction coupling between astrocytes and oligodendrocytes in the anterior cingulate cortex of depressed suicides
Glial dysfunction is a major pathophysiological feature of mood disorders. While altered astrocyte (AS) and oligodendrocyte-lineage (OL) functions have been associated with depression, the crosstalk between th...
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Article
Increased functional coupling of the mu opioid receptor in the anterior insula of depressed individuals
The mu opioid receptor (MOR) is a G protein-coupled receptor that plays an essential role in reward and hedonic processes, and that has been implicated in disorders such as depression and addiction. Over the l...
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Article
Open AccessFunctional genomic mechanisms of opioid action and opioid use disorder: a systematic review of animal models and human studies
In the past two decades, over-prescription of opioids for pain management has driven a steep increase in opioid use disorder (OUD) and death by overdose, exerting a dramatic toll on western countries. OUD is a...
