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Open AccessAntiviral efficacy of favipiravir against Zika and SARS-CoV-2 viruses in non-human primates
The COVID-19 pandemic has exemplified that rigorous evaluation in large animal models is key for translation from promising in vitro results to successful clinical implementation. Among the drugs that have bee...
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Early SIV and HIV infection promotes the LILRB2/MHC-I inhibitory axis in cDCs
Classical dendritic cells (cDCs) play a pivotal role in the early events that tip the immune response toward persistence or viral control. In vitro studies indicate that HIV infection induces the dysregulation...
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SIV Infection in Mandrills
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Open AccessImipramine Inhibits Chikungunya Virus Replication in Human Skin Fibroblasts through Interference with Intracellular Cholesterol Trafficking
Chikungunya virus (CHIKV) is an emerging arbovirus of the Togaviridae family that poses a present worldwide threat to human in the absence of any licensed vaccine or antiviral treatment to control viral infection...
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Chapter
Vaccines Against Chikungunya Virus Infection
Chikungunya virus (CHIKV) has since it re-emerged 10 years ago continued to spread globally and is now present on all continents causing millions of infections worldwide. There is no licensed vaccine available...
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Living Reference Work Entry In depth
SIV Infection in Mandrills
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Open AccessEffect of a short-term HAART on SIV load in macaque tissues is dependent on time of initiation and antiviral diffusion
HIV reservoirs are rapidly established after infection, and the effect of HAART initiated very early during acute infection on HIV reservoirs remains poorly documented, particularly in tissue known to actively...
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Open AccessImpact of short term HAART initiated during the acute or chronic stage on SIV infection of the male genital tract
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Open AccessDynamics of viral replication in blood and lymphoid tissues during SIVmac251 infection of macaques
Extensive studies of primary infection are crucial to our understanding of the course of HIV disease. In SIV-infected macaques, a model closely mimicking HIV pathogenesis, we used a combination of three marker...
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Open AccessTissue viral dynamics in SIV infected macaques with highly active antiretroviral therapy (HAART)
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Open AccessInflammatory control in AIDS-resistant non human primates
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Open AccessNef-mediated TCR-CD3 and MHC-I down-modulation prevents CD4+ T cell depletion in natural SIV infection
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Identification of a new human immunodeficiency virus type 1 distinct from group M and group O
A highly divergent HIV-1 isolate, designated YBF 30, was obtained in 1995 from a 40-year-old Cameroonian woman with AIDS. Depending on the genes studied, phylogenetic analysis showed that YBF30 branched either...
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AIDS vaccine developments
