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Article
Open AccessThe evaluation of kidney function estimation during lifestyle intervention in children with overweight and obesity
Children with overweight and obesity are at risk for develo** chronic kidney disease (CKD). During lifestyle adjustment, the first step in the treatment of childhood obesity, body proportions are likely to c...
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Article
Extending the cystatin C based EKFC-equation to children – validation results from Europe
A new cystatin C based European Kidney Function Consortium (EKFCCysC) equation was recently developed for adults, using the same mathematical form as the previously published full age spectrum creatinine based EK...
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Article
Estimated glomerular filtration rate: applicability of creatinine-based equations in African children
The Schwartz equation is the most widely used serum creatinine (SCr)-based formula to estimate the glomerular filtration rate (GFR) in children of European descent, but whether this applies to African children...
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Article
Glomerular hyperfiltration: part 1 — defining the threshold — is the sky the limit?
Glomerular hyperfiltration (GHF) is an increase in single-nephron glomerular filtration rate (GFR) that occurs in both physiological states and pathological states. Whole-kidney GHF is often used as a surrogat...
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Article
Glomerular hyperfiltration: part 2—clinical significance in children
Glomerular hyperfiltration (GHF) is a phenomenon that can occur in various clinical conditions affecting the kidneys such as sickle cell disease, diabetes mellitus, autosomal dominant polycystic kidney disease...
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Article
Bridging the gap of referral to nephrology care
Optimal referral of patients who are at risk of kidney failure to nephrologists could improve their long-term outcomes. Various strategies, including the inclusion of kidney failure risk equations in electroni...
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Article
The effect of different consensus definitions on diagnosing acute kidney injury events and their association with in-hospital mortality
Due to the existence of different AKI definitions, analyzing AKI incidence and associated outcomes is challenging. We investigated the incidence of AKI events defined by 4 different definitions (standard AKIN ...
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Article
Evaluation of the creatinine-based chronic kidney disease in children (under 25 years) equation in healthy children and adolescents
The Chronic Kidney Disease in children (CKiD) equation to estimate glomerular filtration rate eGFR = k × Ht / SCr (Ht = height in cm, SCr = serum creatinine in mg/dL), with fixed k = 0.413, has recently been opti...
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Article
Characteristics of outpatients referred for a first consultation with a nephrologist: impact of different guidelines
Chronic kidney disease (CKD) affects > 10% of the population but not all CKD patients require referral to a nephrologist. Various recommendations for referral to nephrologists are proposed worldwide. We examin...
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Article
Nephron overload as a therapeutic target to maximize kidney lifespan
Kidney lifespan is a patient-oriented outcome that provides much needed context for understanding chronic kidney disease (CKD). Nephron endowment, age-associated decline in nephron number, kidney injury histor...
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Article
Survivors of COVID-19 mostly recover from tubular proteinuria and acute kidney injury after hospital discharge
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Article
Open AccessPost-intensive care syndrome after a critical COVID-19: cohort study from a Belgian follow-up clinic
Many patients with coronavirus disease 2019 (COVID-19) required critical care. Mid-term outcomes of the survivors need to be assessed. The objective of this single-center cohort study was to describe their phy...
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Article
Open AccessIohexol plasma clearance for measuring glomerular filtration rate: effect of different ways to calculate the area under the curve
Measuring glomerular filtration rate (GFR) using iohexol plasma clearance has been proposed as the preferred way for GFR determination. The extended multiple-sample protocol is based on fitting the full concen...
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Article
Urinary strips for protein assays: easy to do but difficult to interpret!
Urine samples can be readily obtained from patients in everyday clinical practice. Therefore, the availability of urine allows physicians to obtain relevant clinical information in a timely manner. Since the m...
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Article
Open AccessProteinuria in COVID-19: prevalence, characterization and prognostic role
Proteinuria has been commonly reported in patients with COVID-19. However, only dipstick tests have been frequently used thus far. Here, the quantification and characterization of proteinuria were investigated...
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Article
Evaluation of inactive Matrix-Gla-Protein (MGP) as a biomarker for incident and recurrent kidney stones
Matrix-Gla-protein (MGP) is an inhibitor of vascular calcification. Its dephosphorylated and uncarboxylated inactive form, dpucMGP, is a marker of vitamin K status and of cardio-vascular outcomes in chronic ki...
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Article
Validation of standardized creatinine and cystatin C GFR estimating equations in a large multicentre European cohort of children
Most validations of paediatric glomerular filtration rate (GFR) estimating equations using standardized creatinine (CR) and cystatin C (CYS) assays have comprised relatively small cohorts, which makes accuracy...
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Article
Evaluation of a New Fully Automated Assay for Plasma Intact FGF23
Several FGF23 immunoassays are available. However, they are reserved for research purposes as none have been approved for clinical use. We evaluated the performances of a new automated assay for intact FGF23 o...
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Article
Open AccessVariations of parathyroid hormone and bone biomarkers are concordant only after a long term follow-up in hemodialyzed patients
End-stage renal disease is associated with mineral and bone disorders. Guidelines recommending therapies should be based on serial assessments of biomarkers, and thus on variations (Δ), rather than scattered v...
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Article
The global burden of chronic kidney disease: estimates, variability and pitfalls
Chronic kidney disease (CKD) is presently defined by a matrix of biomarkers, specifically, glomerular filtration rate (GFR) <60 ml/min/1.73 m2 and albuminuria ...
