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Article
Open AccessEffect modification of polypharmacy on incident frailty by chronic kidney disease in older adults
Frailty and polypharmacy are common conditions in older adults, especially in those with chronic kidney disease (CKD). Therefore, we analyzed the association of polypharmacy and incident frailty and the effect...
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Article
Open AccessImproved correction formulas to estimate iohexol clearance from simple models
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Article
Open AccessIncidence of hospital-acquired acute kidney injury and trajectories of glomerular filtration rate in older adults
In older adults, epidemiological data on incidence rates (IR) of hospital-acquired acute kidney injury (AKI) are scarce. Also, little is known about trajectories of kidney function before hospitalization with ...
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Article
Open AccessEntwicklung von Qualitätsindikatoren für die Versorgung von Patient:innen mit chronischer Nierenerkrankung
Die chronische Nierenkrankheit (CKD) ist eine häufige Erkrankung, insbesondere im höheren Alter. Um der Progression der Erkrankung und deren Komplikationen vorzubeugen, ist eine leitliniengerechte ambulante Ve...
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Nierenfunktion im Alter – normaler und pathologischer Nierenfunktionsverlust
Bei der Bestimmung der Nierenfunktion im Alter sollte mitbedacht werden, dass die GFR physiologischerweise ab dem 40. Lebensjahr mit konstanter Rate abnimmt. Für die klinische Unterscheidung zu einem krankhaft...
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Article
Open AccessGender differences in frailty transition and its prediction in community-dwelling old adults
Frailty is very common in old age and often associated with adverse events. Transitioning between frailty states is possible in both directions (improvement and worsening) offering targets for interventions. F...
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Article
Open AccessAdvancement of pharmacokinetic models of iohexol in patients aged 70 years or older with impaired kidney function
Plasma clearance of iohexol is a pivotal metric to quantify glomerular filtration rate (GFR), but the optimal timing and frequency of plasma sampling remain to be assessed. In this study, we evaluated the impa...
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Article
Open AccessDevelopment of a prediction model for mortality and cardiovascular outcomes in older adults taking into account AZGP1
Zinc-alpha 2-glycoprotein (AZGP1) is a serum protein with postulated functions in metabolism, cancer and cardiovascular disease. We developed new prediction models for mortality or cardiovascular events invest...
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Article
Open AccessIohexol plasma clearance for measuring glomerular filtration rate: effect of different ways to calculate the area under the curve
Measuring glomerular filtration rate (GFR) using iohexol plasma clearance has been proposed as the preferred way for GFR determination. The extended multiple-sample protocol is based on fitting the full concen...
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Article
Open AccessSelf-reported medication in community-dwelling older adults in Germany: results from the Berlin Initiative Study
Older adults have the highest drug utilization due to multimorbidity. Although the number of people over age 70 is expected to double within the next decades, population-based data on their medication patterns...
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Article
Open AccessAuthor Correction: Beta Trace Protein does not outperform Creatinine and Cystatin C in estimating Glomerular Filtration Rate in Older Adults
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
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Article
Open AccessUsing a three-compartment model improves the estimation of iohexol clearance to assess glomerular filtration rate
Plasma clearance of iohexol is a key tool to precisely determine glomerular filtration rate (GFR) in clinical research and clinical practice. Despite evidence that iohexol pharmacokinetics are described best b...
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Article
Open AccessBeta Trace Protein does not outperform Creatinine and Cystatin C in estimating Glomerular Filtration Rate in Older Adults
Despite intense research the optimal endogenous biomarker for glomerular filtration rate (GFR) estimation has not been identified yet. We analyzed if ß-trace protein (BTP) improved GFR estimation in elderly. 5...
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Article
Open AccessTwo elderly patients with normal creatinine and elevated cystatin C – a case report
Serum creatinine concentration (Scr) and creatinine based GFR estimating equations (eGFRcr) are commonly used as an estimate of GFR. However, serum creatinine concentration is also influenced by non-GFR determina...
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Article
Estimating GFR in children
In a new study, Schwartz and colleagues have investigated the best way to estimate glomerular filtration rate (GFR) in children. Having already improved GFR estimation with the use of creatinine-based equation...
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Article
The Berlin initiative study: the methodology of exploring kidney function in the elderly by combining a longitudinal and cross-sectional approach
Epidemiologic data on incidence, prevalence and risk factors for chronic kidney disease (CKD) and its progression to kidney failure in people ≥70 years are scarce. This lack may have two reasons: First, the is...
