-
Article
Association of delayed adequate antimicrobial treatment and organ dysfunction in pediatric bloodstream infections
Bloodstream infections (BSIs) are associated with significant mortality and morbidity, including multiple organ dysfunction. We explored if delayed adequate antimicrobial treatment for children with BSIs is as...
-
Chapter and Conference Paper
Shared Sensemaking and Clinical Decision-Making in Critical Care from a SA-Oriented Dashboard
At the start of the COVID-19 pandemic, Intensive Care Units (ICUs) admitted an unusually high number of patients suffering from the most severe respiratory effect of the disease. The clinicians worked in teams...
-
Article
Multisystemic Inflammatory Syndrome in Children: a step towards a better understanding of this entity
As pediatricians, we all have to deal with new childhood inflammatory disorder due to COVID 19: the Multisystem Inflammatory Syndrome in Children (MIS-C). The recent article by Savorgnan et al. on the physiolo...
-
Article
Open AccessAntimicrobial treatment duration for uncomplicated bloodstream infections in critically ill children: a multicentre observational study
Bloodstream infections (BSIs) cause significant morbidity and mortality in critically ill children but treatment duration is understudied. We describe the durations of antimicrobial treatment that critically i...
-
Article
Acute kidney injury in the pediatric intensive care unit: outpatient follow-up
Few studies have characterized follow-up after pediatric acute kidney injury (AKI). Our aim was to describe outpatient AKI follow-up after pediatric intensive care unit (PICU) admission.
-
Article
Association of pediatric cardiac surgery-associated acute kidney injury with post-discharge healthcare utilization, mortality and kidney outcomes
Acute kidney Injury (AKI) in children undergoing cardiac surgery (CS) is strongly associated with hospital morbidity. Post-discharge CS AKI outcomes are less clear. We evaluated associations between AKI and po...
-
Chapter
Liver Failure and the Lungs
Children with liver failure may have an acute respiratory failure following one or several simultaneous insults including hepatic encephalopathy, volume overload, pulmonary hemorrhage, pulmonary edema, acute l...
-
Chapter
Liver Failure and Extracorporeal Therapies
Acute liver failure is a common disease seen in pediatric intensive care and is secondary to various pathologies. The management aims to maintain hemodynamic and respiratory status, avoid bleeding, and prevent...
-
Chapter and Conference Paper
Remote Design of a Pediatric Intensive Care Unit Dashboard in Time of Pandemics
To support the pediatric intensive care unit with the COVID-19 pandemic, we followed a user-centered design process to create a dashboard in a context where direct access to users was impossible. To this end, ...
-
Chapter
Liver Injury and Failure in Critically Ill Children
Liver injury is frequent in the intensive care unit and its occurrence is associated with poorer outcomes. Multiple and interrelated mechanisms are involved. We review four major pathophysiological pathways of...
-
Chapter
Acute Liver Failure
Acute liver failure is characterized by a rapid deterioration in liver functions leading to an encephalopathy, but it has good chances of survival. This chapter details the aetiologies of acute liver failures ...
-
Chapter
Conventional Mechanical Ventilation
Respiratory failure is one of the most common reasons for admission to the pediatric intensive care unit (PICU), and about half of the patients admitted to PICU need ventilator support. Development of mechanic...
-
Chapter
Dialytic Therapy of Inborn Errors of Metabolism in Case of Acute Decompensation
Some inborn errors of metabolism involve enzyme defects in the catabolic pathway of amino acids that induce a metabolic encephalopathy by accumulation of neurotoxic metabolites (endogenous intoxication). In th...
-
Article
Open AccessConsensus guidelines for management of hyperammonaemia in paediatric patients receiving continuous kidney replacement therapy
Hyperammonaemia in children can lead to grave consequences in the form of cerebral oedema, severe neurological impairment and even death. In infants and children, common causes of hyperammonaemia include urea ...
-
Article
Open AccessComparison of two methods to clear the airways of critically ill children and adults with COVID-19 infection: a structured summary of a study protocol for a pilot randomized controlled trial
As there is no treatment for COVID-19 with a proven mortality benefit at this moment in the pandemic, supportive management including mechanical ventilation is the core management in an intensive care unit (IC...
-
Article
Prognostic relevance and inter-observer reliability of chest-imaging in pediatric ARDS: a pediatric acute respiratory distress incidence and epidemiology (PARDIE) study
Definitions of acute respiratory distress syndrome (ARDS) include radiographic criteria, but there are concerns about reliability and prognostic relevance. This study aimed to evaluate the independent relation...
-
Chapter
Imaging and Monitoring in Pediatric Acute Respiratory Distress Syndrome
Understanding of chest imaging is paramount in the diagnosis and treatment of PARDS and, as recommended by the consensus conference on PARDS (PALICC), children with or at risk of PARDS should receive, at a min...
-
Article
Influence of implementing a protocol for an intravenously administered ammonia scavenger on the management of acute hyperammonemia in a pediatric intensive care unit
The purpose of the study was to evaluate the influence of establishing a protocol for the use of combined sodium benzoate and sodium phenylacetate (SBSP) (Ammonul®) to treat acute hyperammonemia. This was a re...
-
Article
Open AccessPatient–ventilator asynchrony during conventional mechanical ventilation in children
We aimed (1) to describe the characteristics of patient–ventilator asynchrony in a population of critically ill children, (2) to describe the risk factors associated with patient–ventilator asynchrony, and (3)...
-
Article
Evaluation of height-dependent and height-independent methods of estimating baseline serum creatinine in critically ill children
Baseline serum creatinine (bSCr) is required for diagnosing acute kidney injury (AKI). In children, bSCr is commonly defined as the lowest measurement within 3 months of admission. Measured values are often mi...
