35 Result(s)

Article

Oxygenation thresholds for invasive ventilation in hypoxemic respiratory failure: a target trial emulation in two cohorts

The optimal thresholds for the initiation of invasive ventilation in patients with hypoxemic respiratory failure are unknown. Using the saturation-to-inspired oxygen ratio (SF), we compared lower versus higher...

Christopher J. Yarnell, Federico Angriman, Bruno L. Ferreyro, Kuan Liu… in Critical Care (2023)

Article

Heterogeneity of treatment effect of interferon-β1b and lopinavir–ritonavir in patients with Middle East respiratory syndrome by cytokine levels

Animal and human data indicate variable effects of interferons in treating coronavirus infections according to inflammatory status and timing of therapy. In this sub-study of the MIRACLE trial (MERS-CoV Infect...

Yaseen M. Arabi, Ayed Y. Asiri, Abdullah M. Assiri… in Scientific Reports (2022)

Article

Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study

Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (...

Luis Felipe Reyes, Srinivas Murthy, Esteban Garcia-Gallo, Laura Merson… in Critical Care (2022)

Article

Antimicrobial treatment duration for uncomplicated bloodstream infections in critically ill children: a multicentre observational study

Bloodstream infections (BSIs) cause significant morbidity and mortality in critically ill children but treatment duration is understudied. We describe the durations of antimicrobial treatment that critically i...

Sandra Pong, Robert A. Fowler, Srinivas Murthy, Jeffrey M. Pernica… in BMC Pediatrics (2022)

Article

Twenty articles that critical care clinicians should read about COVID-19

Jennifer L. Y. Tsang, Alexandra Binnie, Robert A. Fowler in Intensive Care Medicine (2021)

Article

A pilot randomized controlled trial of 7 versus 14 days of antibiotic treatment for bloodstream infection on non-intensive care versus intensive care wards

The optimal treatment duration for patients with bloodstream infection is understudied. The Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE) pilot randomized clinical trial (RC...

Nick Daneman, Asgar H. Rishu, Ruxandra Pinto, Yaseen Arabi, Emilie P. Belley-Cote… in Trials (2020)

Article

Treatment of Middle East respiratory syndrome with a combination of lopinavir/ritonavir and interferon-β1b (MIRACLE trial): statistical analysis plan for a recursive two-stage group sequential randomized controlled trial

The MIRACLE trial (MERS-CoV Infection tReated with A Combination of Lopinavir/ritonavir and intErferon-β1b) investigates the efficacy of a combination therapy of lopinavir/ritonavir and recombinant interferon-...

Yaseen M. Arabi, Ayed Y. Asiri, Abdullah M. Assiri, Hani A. Aziz Jokhdar… in Trials (2020)

Article

Variability in intensive care unit admission among pregnant and postpartum women in Canada: a nationwide population-based observational study

Pregnancy-related critical illness results in approximately 300,000 deaths globally each year. The objective was to describe the variation in ICU admission and the contribution of patient- and hospital-based f...

Kazuyoshi Aoyama, Ruxandra Pinto, Joel G. Ray, Andrea D. Hill… in Critical Care (2019)

Article

Anti-Ebola therapy for patients with Ebola virus disease: a systematic review

Management of Ebola virus disease (EVD) has historically focused on infection prevention, case detection and supportive care. Several specific anti-Ebola therapies have been investigated, including during the ...

James S. Lee, Neill K. J. Adhikari, Henry Y. Kwon, Koren Teo… in BMC Infectious Diseases (2019)

Article

7 versus 14 days of antibiotic treatment for critically ill patients with bloodstream infection: a pilot randomized clinical trial

Shorter-duration antibiotic treatment is sufficient for a range of bacterial infections, but has not been adequately studied for bloodstream infections. Our systematic review, survey, and observational study i...

Nick Daneman, Asgar H. Rishu, Ruxandra Pinto, Pierre Aslanian, Sean M. Bagshaw… in Trials (2018)

Article

Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial

It had been more than 5 years since the first case of Middle East Respiratory Syndrome coronavirus infection (MERS-CoV) was recorded, but no specific treatment has been investigated in randomized clinical tria...

Yaseen M. Arabi, Adel Alothman, Hanan H. Balkhy, Abdulaziz Al-Dawood… in Trials (2018)

Article

Measurement properties of comorbidity indices in maternal health research: a systematic review

Maternal critical illness occurs in 1.2 to 4.7 of every 1000 live births in the United States and approximately 1 in 100 women who become critically ill will die. Patient characteristics and comorbid condition...

Kazuyoshi Aoyama, Rohan D’Souza, Eiichi Inada… in BMC Pregnancy and Childbirth (2017)

Article

Ebola virus disease and critical illness

As of 20 May 2016 there have been 28,646 cases and 11,323 deaths resulting from the West African Ebola virus disease (EVD) outbreak reported to the World Health Organization. There continue to be sporadic flar...

Aleksandra Leligdowicz, William A. Fischer II, Timothy M. Uyeki… in Critical Care (2016)

Article

The influence of corticosteroid treatment on the outcome of influenza A(H1N1pdm09)-related critical illness

Patients with 2009 pandemic influenza A(H1N1pdm09)-related critical illness were frequently treated with systemic corticosteroids. While observational studies have reported significant corticosteroid-associate...

Jesse W. Delaney, Ruxandra Pinto, Jennifer Long, François Lamontagne… in Critical Care (2016)

Article

Risk factors for and prediction of mortality in critically ill medical–surgical patients receiving heparin thromboprophylaxis

Previous studies have suggested that prediction models for mortality should be adjusted for additional risk factors beyond the Acute Physiology and Chronic Health Evaluation (APACHE) score. Our objective was ...

Guowei Li, Lehana Thabane, Deborah J. Cook, Renato D. Lopes… in Annals of Intensive Care (2016)

Article

Critical care capacity in Canada: results of a national cross-sectional study

Intensive Care Units (ICUs) provide life-supporting treatment; however, resources are limited, so demand may exceed supply in the event of pandemics, environmental disasters, or in the context of an aging popu...

Robert A Fowler, Philip Abdelmalik, Gordon Wood, Denise Foster… in Critical Care (2015)