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  1. Article

    Efruxifermin in non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled, phase 2a trial

    Preclinical and clinical data suggest that fibroblast growth factor 21 (FGF21) is anti-fibrotic, improves metabolic status and has potential to treat non-alcoholic steatohepatitis (NASH). We assessed the safet...

    Stephen A. Harrison, Peter J. Ruane, Bradley L. Freilich, Guy Neff… in Nature Medicine (2021)

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    Article

    Clinical targeting of HIV capsid protein with a long-acting small molecule

    Oral antiretroviral agents provide life-saving treatments for millions of people living with HIV, and can prevent new infections via pre-exposure prophylaxis1–5. However, some people living with HIV who are heavi...

    John O. Link, Martin S. Rhee, Winston C. Tse, Jim Zheng, John R. Somoza… in Nature (2020)