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Article
Open AccessExploring Clinical Remission in Moderate Asthma – Perspectives from Asia, the Middle East, and South America
Clinical remission is a relatively new concept in asthma but recent research initiatives suggest it could be an ambitious and achievable therapeutic target for patients with asthma.
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Article
Open AccessEffect of fractional exhaled nitric oxide (FENO)-based asthma management during pregnancy versus usual care on infant development, temperament, sensory function and autism signs
Asthma during pregnancy is associated with a range of adverse perinatal outcomes. It is also linked to increased rates of neurodevelopmental conditions in the offspring. We aimed to assess whether fractional e...
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Article
Open AccessThe association of exhaled nitric oxide with air pollutants in young infants of asthmatic mothers
Exhaled nitric oxide is a marker of airway inflammation. Air pollution induces airway inflammation and oxidative stress. Little is known about the impact of air pollution on exhaled nitric oxide in young infants.
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Article
Open AccessCharacterization and inhibition of inflammasome responses in severe and non-severe asthma
Increased airway NLRP3 inflammasome-mediated IL-1β responses may underpin severe neutrophilic asthma. However, whether increased inflammasome activation is unique to severe asthma, is a common feature of immun...
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Article
Open AccessThe impact of the 2019/2020 Australian landscape fires on infant feeding and contaminants in breast milk in women with asthma
The 2019/2020 Australian landscape fires (bushfires) resulted in prolonged extreme air pollution; little is known about the effects on breastfeeding women and their infants. This study aimed to examine the imp...
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Article
Open AccessAssociations of symptoms of anxiety and depression with health-status, asthma control, dyspnoea, dysfunction breathing and obesity in people with severe asthma
Anxiety and depression are comorbidities of severe asthma. However, clinical characteristics associated with coexisting severe asthma and anxiety/depression are poorly understood. The study objective is to det...
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Article
Open AccessThe impact of prolonged landscape fire smoke exposure on women with asthma in Australia
Little is known about the physical and mental health impact of exposure to landscape fire smoke in women with asthma. This study examined the health impacts and information-seeking behaviours of women with ast...
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Article
Open AccessMepolizumab improves clinical outcomes in patients with severe asthma and comorbid conditions
Comorbidities can complicate the management of severe asthma; therefore, the presence of comorbid conditions or traits often need to be considered when considering treatment options for patients with severe as...
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Article
Open AccessA feasibility randomised controlled trial of Novel Activity Management in severe ASthma-Tailored Exercise (NAMASTE): yoga and mindfulness
Physical inactivity is common in severe asthma and associated with poor health outcomes. New approaches are needed to address physical inactivity in this group.
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Article
Open AccessInternational severe asthma registry (ISAR): protocol for a global registry
Severe asthma exerts a disproportionately heavy burden on patients and health care. Due to the heterogeneity of the severe asthma population, many patients need to be evaluated to understand the clinical featu...
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Article
Open AccessClinical and lung function outcomes in a cohort of children with severe asthma
Uncontrolled severe asthma in children is burdensome and challenging to manage. This study aims to describe outcomes in children with uncontrolled severe asthma managed in a nurse-led severe asthma clinic (SAC).
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Article
Open AccessNasal epithelial cells to assess in vitro immune responses to respiratory virus infection in pregnant women with asthma
Respiratory virus-induced asthma exacerbations occur frequently during pregnancy and are associated with adverse outcomes for mother and child. Primary nasal epithelial cells (pNECs) provide a useful method to...
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Chapter
Asthma: Interrelationships with Pregnancy
Asthma affects pregnancy, and pregnancy affects asthma. These interrelationships affect the health of both mother and baby and have influences over the future health of the offspring.
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Article
Role of Obesity in Asthma: Mechanisms and Management Strategies
Obesity is a commonly reported comorbidity in asthma, particularly in severe asthma. Obese asthmatics are highly symptomatic with a poor quality of life, despite using high-dose inhaled corticosteroids. While ...
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Article
Open AccessThe Breathing for Life Trial: a randomised controlled trial of fractional exhaled nitric oxide (FENO)-based management of asthma during pregnancy and its impact on perinatal outcomes and infant and childhood respiratory health
Asthma exacerbations are common during pregnancy and associated with an increased risk of adverse perinatal outcomes. Adjusting asthma treatment based on airway inflammation rather than symptoms reduces the ex...
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Article
Open AccessPeriostin levels and eosinophilic inflammation in poorly-controlled asthma
Periostin levels are associated with airway eosinophilia and are suppressed by corticosteroid treatment in asthma. This study sought to determine the relationship between serum and sputum periostin, airway inf...
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Article
Open AccessDietary changes in migrant adolescents with increasing length of stay in Australia and associated risk of wheeze – a retrospective, cross sectional study
Recent studies have reported that asthma prevalence increases on migration to Australia. We hypothesised that changes in dietary intake contribute to this phenomenon. The aim of this study was to assess dietar...
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Article
Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites
Asthma is prevalent in Western countries, and recent explanations have evoked the actions of the gut microbiota. Here we show that feeding mice a high-fibre diet yields a distinctive gut microbiota, which incr...
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Article
Open AccessVentilation inhomogeneities in children with congenital thoracic malformations
Congenital thoracic malformations (CTM) are rare lung lesions that are managed with surgical resection or active surveillance.
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Article
Open AccessAnti-inflammatory deficiencies in neutrophilic asthma: reduced galectin-3 and IL-1RA/IL-1β
Galectin-3 (gal-3), a member of the β-galactoside-binding animal lectins, is involved in the recruitment, activation and removal of neutrophils. Neutrophilic asthma is characterized by a persistent elevation o...
