11 Result(s)

Article

Efficacy of Tezepelumab in Patients with Severe, Uncontrolled Asthma Across Multiple Clinically Relevant Subgroups in the NAVIGATOR Study

Many patients with severe asthma continue to experience symptoms and exacerbations despite treatment with standard-of-care therapy. In the phase 3 NAVIGATOR study, tezepelumab significantly reduced exacerbatio...

Tara F. Carr, Wendy C. Moore, Monica Kraft, Guy Brusselle… in Advances in Therapy (2024)

Article

Correction: iDESC: identifying differential expression in single-cell RNA sequencing data with multiple subjects

Yunqing Liu, Jiayi Zhao, Taylor S. Adams, Ningya Wang… in BMC Bioinformatics (2023)

Article

iDESC: identifying differential expression in single-cell RNA sequencing data with multiple subjects

Single-cell RNA sequencing (scRNA-seq) technology has enabled assessment of transcriptome-wide changes at single-cell resolution. Due to the heterogeneity in environmental exposure and genetic background acros...

Yunqing Liu, Jiayi Zhao, Taylor S. Adams, Ningya Wang… in BMC Bioinformatics (2023)

Article

The new era of add-on asthma treatments: where do we stand?

Globally, a small proportion (5–12%) of asthma patients are estimated to have severe disease. However, severe asthma accounts for disproportionately high healthcare resource utilization. The Global Initiative ...

William J. Calhoun, Geoffrey L. Chupp in Allergy, Asthma & Clinical Immunology (2022)

Article

Mepolizumab improves clinical outcomes in patients with severe asthma and comorbid conditions

Comorbidities can complicate the management of severe asthma; therefore, the presence of comorbid conditions or traits often need to be considered when considering treatment options for patients with severe as...

Peter G. Gibson, Charlene M. Prazma, Geoffrey L. Chupp… in Respiratory Research (2021)

Article

Single-cell characterization of a model of poly I:C-stimulated peripheral blood mononuclear cells in severe asthma

Asthma has been associated with impaired interferon response. Multiple cell types have been implicated in such response impairment and may be responsible for asthma immunopathology. However, existing models to...

Ailu Chen, Maria P. Diaz-Soto, Miguel F. Sanmamed, Taylor Adams… in Respiratory Research (2021)

Article

Approaches for integrating heterogeneous RNA-seq data reveal cross-talk between microbes and genes in asthmatic patients

Sputum induction is a non-invasive method to evaluate the airway environment, particularly for asthma. RNA sequencing (RNA-seq) of sputum samples can be challenging to interpret due to the complex and heteroge...

Daniel Spakowicz, Shaoke Lou, Brian Barron, Jose L. Gomez, Tianxiao Li… in Genome Biology (2020)

Article

Pulmonary artery pseudoaneurysm causing massive hemoptysis in hyperimmunoglobulin E syndrome: a case report

Hyperimmunoglobulin E syndrome (HIES) is a rare primary immunodeficiency disorder defined by high serum immunoglobulin E titers that is associated with recurrent respiratory infections, formation of pneumoatoc...

Aaron Hakim, Isabel S. Bazan, Mamadou L. Sanogo… in BMC Pulmonary Medicine (2019)

Article

A novel pathway-based distance score enhances assessment of disease heterogeneity in gene expression

Distance based unsupervised clustering of gene expression data is commonly used to identify heterogeneity in biologic samples. However, high noise levels in gene expression data and relatively high correlation...

**ting Yan, Anqi Liang, Jose Gomez, Lauren Cohn, Hongyu Zhao… in BMC Bioinformatics (2017)

Article

Improvement in asthma control and inflammation in children undergoing adenotonsillectomy

Observational studies suggest that asthma control improves after adenotonsillectomy, but longitudinal studies that correlate the effect of the procedure on the levels of biomarkers associated with airway infla...

Jonathan C. Levin, Lisa Gagnon, **aoxuan He, Eric D. Baum… in Pediatric Research (2014)