-
Article
Open AccessFatigue performance analysis of fine aggregate matrix using a newly designed experimental strategy and viscoelastic continuum damage theory
Fine aggregate matrix (FAM), as the matrix phase in asphalt concrete (AC), significantly affects the fatigue behavior of AC. To accurately assess the mechanical properties of FAM, a newly designed experimental...
-
Article
Open AccessKRAS-mutant non-small cell lung cancer (NSCLC) therapy based on tepotinib and omeprazole combination
KRAS-mutant non-small cell lung cancer (NSCLC) shows a relatively low response rate to chemotherapy, immunotherapy and KRAS-G12C selective inhibitors, leading to short median progression-free survival, and overal...
-
Article
Open AccessUnlocking the potential: T1-weighed MRI as a powerful predictor of levodopa response in Parkinson’s disease
The efficacy of levodopa, the most crucial metric for Parkinson’s disease diagnosis and treatment, is traditionally gauged through the levodopa challenge test, which lacks a predictive model. This study aims t...
-
Article
Open AccessEpigallocatechin gallate modulates ferroptosis through downregulation of tsRNA-13502 in non-small cell lung cancer
Ferroptosis, an iron-dependent regulated cell death mechanism, holds significant promise as a therapeutic strategy in oncology. In the current study, we explored the regulatory effects of epigallocatechin gall...
-
Article
Open AccessSaiga antelope horn suppresses febrile seizures in rats by regulating neurotransmitters and the arachidonic acid pathway
Saiga antelope horn (SAH) is a traditional Chinese medicine for treating febrile seizure (FS) with precise efficacy, but its mechanism of action and functional substances are still unclear. Given the need for ...
-
Article
Correction to: Brain Mechanisms Underlying Panic Attack and Panic Disorder
-
Article
Brain Mechanisms Underlying Panic Attack and Panic Disorder
Panic disorder is a psychiatric disorder characterized by recurrent panic attacks, with a prevalence of ~ 4% in the general population, causing heavy personal and socioeconomic burdens. The similarities of ani...
-
Article
Modification of the CuO electronic structure for enhanced selective electrochemical CO2 reduction to ethylene
Electrochemical carbon dioxide reduction reaction (CO2RR) can produce value-added hydrocarbons from renewable electricity, providing a sustainable and promising approach to meet dual-carbon targets and alleviate ...
-
Article
Effect of Sintering Environment on Microstructures and Mechanical Properties of Metal Injection Molding Ti-6Al-4V Alloys
We employed a water-soluble binder to form Ti-6Al-4V alloy through metal injection molding and studied the effects of sintering (under Ar and various vacuum conditions) on the microstructure and mechanical pro...
-
Article
Simulation of realistic granular soils in triaxial test using physics engine
The discrete element method (DEM) is the most widely applied numerical tool to simulate triaxial test, a common geotechnical test to measure the shear strength of soil. However, the typical DEM model uses sphe...
-
Article
Load frequency control of interconnected hydrothermal power system based on FOPI + FOPD controller
Only the frequency stability of interconnected power systems can ensure that the system remains stable after being subjected to large disturbances. A reliable controller is the key to the frequency stability o...
-
Article
Open AccessA simple and effective VIGS system facilitates the control of citrus canker by silencing CsLOB1
Virus-induced gene silencing (VIGS) is a powerful technology for molecular characterization of gene functions in plants and has the potential to prevent and control plant diseases. Unfortunately, VIGS in many ...
-
Article
Open AccessThe structural–functional-connectivity coupling of the aging brain
Aging primarily affects memory and executive functions, a relationship that may be underpinned by the fact that almost all adults over 60 years old develop small vessel disease (SVD). The fact that a wide rang...
-
Article
A molecularly defined amygdala-independent tetra-synaptic forebrain-to-hindbrain pathway for odor-driven innate fear and anxiety
Fear-related disorders (for example, phobias and anxiety) cause a substantial public health problem. To date, studies of the neural basis of fear have mostly focused on the amygdala. Here we identify a molecul...
-
Article
Open AccessMachine learning reveals diverse cell death patterns in lung adenocarcinoma prognosis and therapy
Cancer cell growth, metastasis, and drug resistance pose significant challenges in the management of lung adenocarcinoma (LUAD). However, there is a deficiency in optimal predictive models capable of accuratel...
-
Article
Open AccessIDH2/R140Q mutation confers cytokine-independent proliferation of TF-1 cells by activating constitutive STAT3/5 phosphorylation
R140Q mutation in isocitrate dehydrogenase 2 (IDH2) promotes leukemogenesis. Targeting IDH2/R140Q yields encouraging therapeutic effects in the clinical setting. However, therapeutic resistance occurs in 12% o...
-
Article
A Composite Nano-ink of Liquid Metal Nanoparticles and Carbon Nanotubes for the Fabrication of Flexible Pressure Sensors
Liquid metal (LM) eutectic gallium–indium (EGaIn) possesses the ductility of a polymer and the conductivity of metal materials, making it a promising material for flexible electronics. Fabricating LM-based cir...
-
Article
STING signaling in islet macrophages impairs insulin secretion in obesity
The innate immune regulator stimulator of interferon genes (STING) mediates self-DNA sensing and leads to the induction of type I interferons and inflammatory cytokines, which promotes the progression of vario...
-
Article
Nonlinear influence of construction land on poverty reduction efficiency in Chinese poor counties: new evidence using a panel threshold model
The utilization of rural construction land in Chinese poor counties, which is mainly used for urbanization development, construction for farmers’ new housing, infrastructure development (transportation, water ...
-
Article
Open AccessPropranolol inhibits EMT and metastasis in breast cancer through miR-499-5p-mediated Sox6
This study will focus on 4T1 cells, a murine mammary adenocarcinoma cell line, as the primary research subject. We aim to investigate the inhibitory effects and mechanisms of propranolol on epithelial–mesenchy...
