-
Article
Open AccessTotal syntheses of Tetrodotoxin and 9-epiTetrodotoxin
Tetrodotoxin and congeners are specific voltage-gated sodium channel blockers that exhibit remarkable anesthetic and analgesic effects. Here, we present a scalable asymmetric syntheses of Tetrodotoxin and 9-epiTe...
-
Article
Open AccessMicroglia govern the extinction of acute stress-induced anxiety-like behaviors in male mice
Anxiety-associated symptoms following acute stress usually become extinct gradually within a period of time. However, the mechanisms underlying how individuals cope with stress to achieve the extinction of anx...
-
Article
Open AccessA deep neural network for MRI spinal inflammation in axial spondyloarthritis
To develop a deep neural network for the detection of inflammatory spine in short tau inversion recovery (STIR) sequence of magnetic resonance imaging (MRI) on patients with axial spondyloarthritis (axSpA).
-
Chapter and Conference Paper
Characteristics and Genesis of Low-Energy Fine-Grained Carbonate Reservoirs: A Case Study from Middle Cretaceous Mishrif Formation in H Oilfield, Iraq
The Mishrif formation in H oilfield of Iraq is primarily characterized by lagoon deposits in the MB1–2 interval, consisting mainly of packstone and a small amount of wackestone. The reservoir exhibits a high d...
-
Reference Work Entry In depth
Digital Integrated Circuit Design
This chapter introduces the classification, design methods, and main features of digital ICs. Circuit partitioning is a valuable method to reduce the complexity of VLSI design, in which hardware description la...
-
Article
Lesion-aware knowledge distillation for diabetic retinopathy lesion segmentation
Retinal fundus images have been widely utilized for screening Diabetic Retinopathy (DR). The lesion information contained in these images is indispensable for the diagnosis of DR. The acquisition of lesion inf...
-
Article
NO hydrogenation to NH3 over FeCu/TiO2 catalyst with improved activity
Ammonia is crucial in industry and agriculture, but its production is hindered by environmental concerns and energy-intensive processes. Hence, develo** an efficient and environmentally friendly catalyst is ...
-
Article
Neural Mechanisms Underlying the Coughing Reflex
Breathing is an intrinsic natural behavior and physiological process that maintains life. The rhythmic exchange of gases regulates the delicate balance of chemical constituents within an organism throughout it...
-
Article
Open AccessGinseng-derived nanoparticles reprogram macrophages to regulate arginase-1 release for ameliorating T cell exhaustion in tumor microenvironment
Lines of evidence indicated that, immune checkpoints (ICs) inhibitors enhanced T cell immune response to exert anti-tumor effects. However, T cell exhaustion has been so far a major obstacle to antitumor immun...
-
Article
Synthesis of Ag nanowires with an aspect ratio higher than 2000 for the fabrication of transparent conductive film
Silver nanowires (AgNWs) are promising materials in the fabrication of flexible and transparent conductive thin films (FTCFs), which are key components of flexible optoelectronic devices. However, the performa...
-
Article
Open AccessThe therapeutic value of bifidobacteria in cardiovascular disease
There has been an increase in cardiovascular morbidity and mortality over the past few decades, making cardiovascular disease (CVD) the leading cause of death worldwide. However, the pathogenesis of CVD is mul...
-
Article
Open AccessChronotype is associated with eating behaviors, physical activity and overweight in school-aged children
A later chronotype has been found to be associated with unhealthy habits and diseases, such as an unhealthy diet and metabolic syndrome in adults. Little is known about the association between chronotype, eati...
-
Article
Open AccessRefactoring the architecture of a polyketide gene cluster enhances docosahexaenoic acid production in Yarrowia lipolytica through improved expression and genetic stability
Long-chain polyunsaturated fatty acids (LC-PUFAs), such as docosahexaenoic acid (DHA), are essential for human health and have been widely used in the food and pharmaceutical industries. However, the limited a...
-
Article
Open AccessChronic cough relief by allosteric modulation of P2X3 without taste disturbance
P2X receptors are cation channels that sense extracellular ATP. Many therapeutic candidates targeting P2X receptors have begun clinical trials or acquired approval for the treatment of refractory chronic cough...
-
Article
Open AccessHuangqi Guizhi Wuwu decoction alleviates oxaliplatin-induced peripheral neuropathy via the gut-peripheral nerve axis
Oxaliplatin-induced peripheral neurotoxicity (OIPN) limits the dose of chemotherapy and seriously affects the quality of life. Huangqi Guizhi Wuwu Decoction (HGWD) is a classical Traditional Chinese Medicine (...
-
Article
Open AccessAuthor Correction: Structural basis for directional chitin biosynthesis
-
Article
Dynamic Modeling and Vibration Characteristics Analysis for the Helicopter Horizontal Tail Drive Shaft System with the Ballistic Impact Vertical Penetrating Damage
In order to give a qualitative understanding of the ballistic impact damage on system dynamics, and provide ideas for the follow-up study of various types of the ballistic impact damage, dynamic modeling and v...
-
Article
Open AccessExosomal ACADM sensitizes gemcitabine-resistance through modulating fatty acid metabolism and ferroptosis in pancreatic cancer
This study aimed to evaluate the potential of exosomes from cancer cells to predict chemoresistance in pancreatic cancer (PC) and explore the molecular mechanisms through RNA-sequencing and mass spectrometry. ...
-
Article
Correction to: Global honeybee health decline factors and potential conservation techniques
-
Article
Wet-chemical synthesis of spinel Li4Ti5O12 as a negative electrode
A simple two-step method for preparing nanostructured Li4Ti5O12 (LTO), a promising anode material for lithium-ion batteries (LIBs), is reported. The X-ray diffraction (XRD) results reveal that the structure of th...
