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Article
Open AccessLow-to-Moderate Arsenic Exposure and Urothelial Tract Cancers with a Long Latent Period of Follow-Up in an Arseniasis Area
Arsenic exposure can cause adverse health effects. The effects of long-term low-to-moderate exposure and methylations remain unclear.
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Article
Open AccessAdverse body measurements are superior to sarcopenia-associated measurements in predicting chronic diseases
Few studies have demonstrated an association of sarcopenia-associated body measurements with chronic diseases through a comprehensive methodology. This study aims to examine the relationship between sarcopenia...
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Article
Open AccessA Ras-LSD1 axis activates PI3K signaling through PIK3IP1 suppression
PI3K Interacting Protein 1 (PIK3IP1) is a suppressor of the PI3K/Akt/mTOR pathway. We previously reported that activated Ras suppresses PIK3IP1 expression to positively regulate the PI3K pathway in cancer cell...
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Article
Open AccessDual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality
Achieving robust cancer-specific lethality is the ultimate clinical goal. Here, we identify a compound with dual-inhibitory properties, named a131, that selectively kills cancer cells, while protecting normal ...
