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Article
Open AccessLow-to-Moderate Arsenic Exposure and Urothelial Tract Cancers with a Long Latent Period of Follow-Up in an Arseniasis Area
Arsenic exposure can cause adverse health effects. The effects of long-term low-to-moderate exposure and methylations remain unclear.
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Article
Educational choice, rural–urban migration and economic development
We develop an overlap**-generations framework of education-based migration that takes place prior to labor-market participation and explore its role for economic development, urbanization and workforce compo...
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Article
Open AccessAdverse body measurements are superior to sarcopenia-associated measurements in predicting chronic diseases
Few studies have demonstrated an association of sarcopenia-associated body measurements with chronic diseases through a comprehensive methodology. This study aims to examine the relationship between sarcopenia...
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Article
Open AccessA Ras-LSD1 axis activates PI3K signaling through PIK3IP1 suppression
PI3K Interacting Protein 1 (PIK3IP1) is a suppressor of the PI3K/Akt/mTOR pathway. We previously reported that activated Ras suppresses PIK3IP1 expression to positively regulate the PI3K pathway in cancer cell...
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Article
Open AccessDual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality
Achieving robust cancer-specific lethality is the ultimate clinical goal. Here, we identify a compound with dual-inhibitory properties, named a131, that selectively kills cancer cells, while protecting normal ...
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Article
Modulation of tissue factor and thrombomodulin expression in human aortic endothelial cells incubated with high glucose
Diabetes is often associated with atherothrombosis. It is unknown whether high glucose can modulate the expression of tissue factor (TF) and thrombomodulin (TM) in human aortic endothelial cells (HAECs). HAECs...
