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Article
Open AccessBarriers to implementing asthma self-management in Malaysian primary care: qualitative study exploring the perspectives of healthcare professionals
Asthma self-management is a crucial component of asthma management. We sought to explore healthcare professionals’ (HCPs’) perceptions on barriers to asthma self-management implementation in primary care. We r...
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Article
Open AccessAccuracy of breast MRI in evaluating nodal status after neoadjuvant therapy in invasive lobular carcinoma
Neoadjuvant therapy in breast cancer can downstage axillary lymph nodes and reduce extent of axillary surgery. As such, accurate determination of nodal status after neoadjuvant therapy and before surgery impac...
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Article
Evaluating the impact of axillary dissection on recurrence-free survival by extent of nodal disease in invasive lobular carcinoma of the breast
Clinical trials have shown that axillary lymph node dissection (ALND) can be avoided for many breast cancer patients with limited nodal involvement. However, whether its omission is safe for those with invasiv...
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Article
Mitotic score and pleomorphic histology in invasive lobular carcinoma of the breast: impact on disease-free survival
Pleomorphic invasive lobular carcinoma (ILC) has long been thought to have worse outcomes than classic ILC and is therefore often treated with chemotherapy. However, recent data question the utility of the ple...
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Article
Open AccessSuccess rates of re-excision after positive margins for invasive lobular carcinoma of the breast
Rates of positive margins after surgical resection of invasive lobular carcinoma (ILC) are high (ranging from 18 to 60%), yet the efficacy of re-excision lumpReceptor subtypeectomy for clearing positive margin...
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Article
Open AccessCase report: recurrent metastatic breast cancer in internal mammary dissection bed discovered at the time of coronary bypass
Many patients who undergo coronary artery bypass surgery have a prior history of cancer and potentially chest radiation which is a known risk factor for coronary atherosclerosis. Prior radiation increases fibr...
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Article
Open AccessDual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality
Achieving robust cancer-specific lethality is the ultimate clinical goal. Here, we identify a compound with dual-inhibitory properties, named a131, that selectively kills cancer cells, while protecting normal ...
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Article
Characterizing the immune microenvironment in high-risk ductal carcinoma in situ of the breast
The recent increase in the incidence of ductal carcinoma in situ (DCIS) has sparked debate over the classification and treatment of this disease. Although DCIS is considered a precursor lesion to invasive brea...
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Article
Laparoendoscopic excision of sternal subcutaneous dermoids in children
