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Article
Preliminary Study of the Impact of Single-Nucleotide Polymorphisms of IL-1α, IL-1β and TNF-α Genes on the Occurrence, Severity and Treatment Effectiveness of the Major Depressive Disorder
The purpose of the preliminary study was to determine whether the occurrence of certain SNPs of genes encoding IL-1α, IL-1β, and TNF-α is associated with the development of depression. Five polymorphisms were sel...
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Article
Open AccessThe Effect of Chronic Mild Stress and Venlafaxine on the Expression and Methylation Levels of Genes Involved in the Tryptophan Catabolites Pathway in the Blood and Brain Structures of Rats
A growing body of evidence suggests that depression may be associated with impairment of the tryptophan catabolites (TRYCATs) pathway. The present study investigated the effects of the chronic administration o...
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Article
Open AccessDisturbance of cellular homeostasis as a molecular risk evaluation of human endothelial cells exposed to nanoparticles
Even though application of nanoparticles in medicine seems to provide unique solutions for drug delivery and diagnosis diseases, understanding interactions between nanoscale materials and biological systems is...
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Article
Open AccessDoxorubicin–transferrin conjugate alters mitochondrial homeostasis and energy metabolism in human breast cancer cells
Doxorubicin (DOX) is considered one of the most powerful chemotherapeutic agents but its clinical use has several limitations, including cardiomyopathy and cellular resistance to the drug. By using transferrin...
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Article
Open AccessOxidative stress parameters as biomarkers of bladder cancer development and progression
The epidemiological studies confirm that the overproduction of free radical is an important factor of cancer induction as well as development, and loss of antioxidant systems efficiency is associated with an i...
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Article
Open AccessVariation of genes encoding nitric oxide synthases and antioxidant enzymes as potential risks of multiple sclerosis development: a preliminary study
Multiple sclerosis (MS) is a neurodegenerative disease characterized by a variable clinical course and diverse pathophysiology, including nitrative and oxidative stresses as well as inflammation. We aimed to d...
