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Article
Open AccessEnhancement of Cloud-native applications with Autonomic Features
The Autonomic Computing paradigm reduces complexity in installing, configuring, optimizing, and maintaining heterogeneous systems. Despite first discussing it a long ago, it is still a top research challenge, ...
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Article
Open AccessAutomatic air volume control system for ventilation of two patients using a single ventilator: a large animal model study
The COVID-19 pandemic outbreak led to a global ventilator shortage. Hence, various strategies for using a single ventilator to support multiple patients have been considered. A device called Ventil previously ...
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Chapter and Conference Paper
Hybrid Cardiovascular Simulator - An Application for the Mechanical Assistance by an Intra-aortic Balloon Pump
The United States Food and Drug Administration agency is encouraging to use modeling and simulation in medical device evaluation, in order to reduce reliance on animal models and human data, and reduce costs a...
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Article
Open Access3D Dense Map** with the Graph of Keyframe-Based and View-Dependent Local Maps
This article concerns the problem of a dense map** system for a robot exploring a new environment. In this scenario, a robot equipped with an RGB-D camera uses RGB and range data to build a consistent model ...
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Article
Open AccessDoxorubicin–transferrin conjugate alters mitochondrial homeostasis and energy metabolism in human breast cancer cells
Doxorubicin (DOX) is considered one of the most powerful chemotherapeutic agents but its clinical use has several limitations, including cardiomyopathy and cellular resistance to the drug. By using transferrin...
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Article
Open AccessDisturbance of cellular homeostasis as a molecular risk evaluation of human endothelial cells exposed to nanoparticles
Even though application of nanoparticles in medicine seems to provide unique solutions for drug delivery and diagnosis diseases, understanding interactions between nanoscale materials and biological systems is...
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Article
Open AccessAutonomic Management Framework for Cloud-Native Applications
In order to meet the rapidly changing requirements of the Cloud-native dynamic execution environment, without human support and without the need to continually improve one’s skills, autonomic features need to ...
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Chapter and Conference Paper
A Novel Real-Time Computer Model of the Coronary System Including a Physiological Feedback Between the Left Ventricular Muscles and Coronary Perfusion
Coronary dysfunction is one of the most common coronary diseases in people living in highly developed regions of the world, where heart infarction and sudden cardiac death often result from stenosis. Besides ...
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Article
Open AccessVM Reservation Plan Adaptation Using Machine Learning in Cloud Computing
In this paper we propose a novel reservation plan adaptation system based on machine learning. In the context of cloud auto-scaling, an important issue is the ability to define and use a resource reservation p...
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Chapter and Conference Paper
A Hybrid Cardio-Pulmonary Simulation Platform—An Application for Extracorporeal Assist Devices
U.S. Food and Drug Administration agency is encouraging to use modeling and simulation in medical device evaluation, in order to reduce validation process and reduce a number of animal and human trials. To add...
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Chapter and Conference Paper
VirRespir—An Application for Virtual Pneumonological Experimentation and Clinical Training
Computer models are a useful tool in research and education. They have a particular value in medicine and biology due to legal and ethical restrictions. Considering the above, a general-purpose virtual patient...
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Article
Open AccessPatterns of pleural pressure amplitude and respiratory rate changes during therapeutic thoracentesis
Although the impact of therapeutic thoracentesis on lung function and blood gases has been evaluated in several studies, some physiological aspects of pleural fluid withdrawal remain unknown. The aim of the st...
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Article
A new infant hybrid respiratory simulator: preliminary evaluation based on clinical data
A new hybrid (numerical–physical) simulator of the respiratory system, designed to simulate spontaneous and artificial/assisted ventilation of preterm and full-term infants underwent preliminary evaluation. A ...
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Chapter and Conference Paper
Power Aware MOM for Telemetry-Oriented Applications—Levee Monitoring Use Case
The paper discusses the problem of the message-oriented middleware utilization in telemetry systems. The authors provide a survey and practical measurements of common data transmission protocols for telemetry ...
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Book
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Chapter
Introduction
The main purpose of this book is to present advanced software tools for development, deployment and governance of Service Oriented Architecture (SOA, for short) applications. Novel technical concepts and parad...
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Article
Continuous-flow pump model study: the effect on pump performance of pump characteristics and cardiovascular conditions
This model study evaluates the effect of pump characteristics and cardiovascular data on hemodynamics in atrio–aortic VAD assistance. The model includes a computational circulatory sub-model and an electrical ...
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Chapter and Conference Paper
Automatic Adaptation of SOA Systems Supported by Machine Learning
Recent advances in the development of information systems have led to increased complexity and cost in terms of the required maintenance and management. On the other hand, systems built in accordance with mode...
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Article
Adaptive Enterprise Service Bus
Modern software systems are usually designed in the Service-Oriented Architecture (SOA), which provides methods for system development and integration of existing, reusable services. Due to the growing com-ple...
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Article
A modular computational circulatory model applicable to VAD testing and training
Aim of this work was to develop a modular computational model able to interact with ventricular assist devices (VAD) for research and educational applications. The lumped parameter model consists of five funct...