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Article
Open AccessHistone H3 posttranslational modified enzymes defined neutrophil plasticity and their vulnerability to IL-10 in the course of the inflammation
Neutrophils are a heterogeneous population capable of antimicrobial functions associated with pre-activation/activation and tissue regeneration. The specific polarisation of immune cells is mediated by the mod...
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Article
Open AccessA new class of polyphenolic carbosilane dendrimers binds human serum albumin in a structure-dependent fashion
The use of dendrimers as drug and nucleic acid delivery systems requires knowledge of their interactions with objects on their way to the target. In the present work, we investigated the interaction of a new c...
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Article
Open AccessSynthesis and biophysical evaluation of carbosilane dendrimers as therapeutic siRNA carriers
Gene therapy presents an innovative approach to the treatment of previously incurable diseases. The advancement of research in the field of nanotechnology has the potential to overcome the current limitations ...
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Article
Open AccessHippophae rhamnoides L. leaf and twig extracts as rich sources of nutrients and bioactive compounds with antioxidant activity
Plants have served for centuries as sources of compounds useful for human health such as antioxidant, anti-diabetic and antitumor agents. They are also rich in nutrients that improve the human diet. Growing de...
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Article
Open AccessDisturbance of cellular homeostasis as a molecular risk evaluation of human endothelial cells exposed to nanoparticles
Even though application of nanoparticles in medicine seems to provide unique solutions for drug delivery and diagnosis diseases, understanding interactions between nanoscale materials and biological systems is...
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Article
Open AccessAdditive interactions of nanoparticulate ZnO with copper, manganese and iron in Pisum sativum L., a hydroponic study
Widespread occurrence of ZnO nanoparticles in environment follows the growing number of applications either in technology or agriculture. The impact of five forms of nanoparticulate ZnO on copper, manganese an...
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Article
Open AccessG protein-coupled estrogen receptor mediates anti-inflammatory action in Crohn’s disease
Estrogens exert immunomodulatory action in many autoimmune diseases. Accumulating evidence highlights the meaningful impact of estrogen receptors in physiology and pathophysiology of the colon. However, the si...
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Article
Open AccessAnalysis of Triticum aestivum seedling response to the excess of zinc
The effects of 50 and 300 mg L−1 Zn2+ (50 Zn and 300 Zn) were investigated in Triticum aestivum (cv. Żura) grown hydroponically for 7 days. Although wheat treated with 50 Zn took up relatively high amount of the ...
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Article
Open AccessThe effect of EDTA and EDDS on lead uptake and localization in hydroponically grown Pisum sativum L.
Pisum sativum plants were treated for 3 days with an aqueous solution of 100 μM Pb(NO3)2 or with a mixture of lead nitrate and ethylenediaminetetraacetic acid (EDTA) or [S,S]-ethylenediaminedisuc...
