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Article
Open AccessAbnormal respiratory progenitors in fibrotic lung injury
Recent advances in single-cell RNA sequencing (scRNA-seq) and epithelium lineage labeling have yielded identification of multiple abnormal epithelial progenitor populations during alveolar type 2 (ATII) cell d...
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Article
Open AccessDisruption of respiratory epithelial basement membrane in COVID-19 patients
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Article
Open AccessCorrection to: Cardiovascular Risks, Bleeding Risks, and Clinical Events from 3 Phase III Trials of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis
In the Original Publication the colors of Figure 2 have been switched. The correct figures are given below.
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Article
Open AccessCardiovascular Risks, Bleeding Risks, and Clinical Events from 3 Phase III Trials of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis
This study assessed baseline cardiovascular (CV) risk factors, concomitant CV medication use, risk of major adverse cardiac events-plus (MACE-plus), and bleeding adverse events (AEs) in patients with idiopathi...
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Article
Open AccessEffect of pirfenidone in patients with more advanced idiopathic pulmonary fibrosis
Data from controlled clinical studies in patients with more advanced idiopathic pulmonary fibrosis (IPF) could inform clinical practice, but they are limited, since this sub-population is usually excluded from...
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Article
Hyaluronan and TLR4 promote surfactant-protein-C-positive alveolar progenitor cell renewal and prevent severe pulmonary fibrosis in mice
Reduced hyaluronan–TLR4 signaling in a stem cell population of the lung contributes to a lack of renewal of these cells and promotes fibrosis in patients with idiopathic pulmonary fibrosis.
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Article
Open AccessMethylation-mediated BMPER expression in fibroblast activation in vitro and lung fibrosis in mice in vivo
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease. Although the pathogenesis is poorly understood, evidence suggests that genetic and epigenetic alterations, such as DNA methylation, may play a...
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Article
Open AccessFamilial and sporadic idiopathic pulmonary fibrosis: making the diagnosis from peripheral blood
Peripheral blood biomarkers might improve diagnostic accuracy for idiopathic pulmonary fibrosis (IPF).
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Article
Role of CD44 in the organization of keratinocyte pericellular hyaluronan
CD44 is a ubiquitous cell surface glycoprotein, involved in important cellular functions including cell adhesion, migration, and modulation of signals from cell surface receptors. While most of these CD44 func...
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Article
Open AccessBayesian probit regression model for the diagnosis of pulmonary fibrosis: proof-of-principle
The accurate diagnosis of idiopathic pulmonary fibrosis (IPF) is a major clinical challenge. We developed a model to diagnose IPF by applying Bayesian probit regression (BPR) modelling to gene expression profi...
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Article
Open AccessIdiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a non-neoplastic pulmonary disease that is characterized by the formation of scar tissue within the lungs in the absence of any known provocation. IPF is a rare disease w...
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Article
The role of Toll-like receptors in non-infectious lung injury
The role of Toll-like receptors (TLRs) in pathogen recognition has been expeditiously advanced in recent years. However, investigations into the function of TLRs in non-infectious tissue injury have just begun...
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Innate Immune Regulation of Lung Injury and Repair
Mechanisms that regulate host defense to noninfectious tissue injury are poorly understood. Here we summarize our recent work investigating the role of the innate immune response in regulating the inflammatory...
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Article
Regulation of lung injury and repair by Toll-like receptors and hyaluronan
Mechanisms that regulate inflammation and repair after acute lung injury are incompletely understood. The extracellular matrix glycosaminoglycan hyaluronan is produced after tissue injury and impaired clearanc...
