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Open AccessNovel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review
Diffuse large B-cell lymphoma (DLBCL) is a clinically heterogeneous lymphoid malignancy and the most common subtype of non-Hodgkin’s lymphoma in adults, with one of the highest mortality rates in most develope...
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Correction: Corrigendum: The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks
Nat. Struct. Mol. Biol. 19, 685–692 (2012); published online 10 June 2012; corrected after print 10 July 2015 In the version of this article initially published, the image in the bottom row of Figure 4a (full-...
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Open AccessDTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells
Prostate cancer (PCa) is one of the leading causes of cancer-related mortality and morbidity in the aging male population and represents the most frequently diagnosed malignancy in men around the world. The De...
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Open AccessCharacterization of recombinant human and bovine thyroid-stimulating hormone preparations by mass spectrometry and determination of their endotoxin content
The TSH stimulation test to confirm canine hypothyroidism is commonly performed using a recombinant human TSH (rhTSH), as up to date, canine TSH is not yet commercially available. Limiting factors for the use ...
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Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases
ADP-ribosylation is an important post-translational protein modification, yet enzymes capable of removing the protein-proximal ADP-ribose were unknown. Human macrodomain proteins MacroD1, D2 and C6orf130 are n...
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The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks
PARP1 is activated by sensing DNA damage, forming ADP-ribose chains that recruit DNA repair and chromatin remodeling factors. PARP1 recognizes DNA damage through its DNA-binding domain, which contains two zinc...
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Article
A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation
Poly-ADP-ribosylation is a post-translational modification catalyzed by enzymes such as PARP1, which responds to metabolic and genotoxic stress. Now macrodomain-containing proteins are shown to rapidly move to...
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Open AccessImportin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLS
The enzymes responsible for the synthesis of poly-ADP-ribose are named poly-ADP-ribose polymerases (PARP). PARP-2 is a nuclear protein, which regulates a variety of cellular functions that are mainly controlle...
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PARP-1 as Novel Coactivator of NF-κB in Inflammatory Disorders
Mammalian poly (ADP-ribose) polymerase-1 (PARP-1) is a nuclear chromatin associated protein and belongs to a large family of enzymes that can synthesize large branched polymers of ADP-ribose units by using β-n...
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PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase
The transcription factor E2F-1 is implicated in the activation of S-phase genes as well as induction of apoptosis, and is regulated by interactions with Rb and by cell cycle-dependent alterations in E2F-1 abun...
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Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis
The transcriptional coactivator p300 interacts with many transcription factors that participate in a broad spectrum of biological activities, such as cellular differentiation, homeostasis and growth control1,2. M...
