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  1. No Access

    Article

    TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

    Enzymes catalysing the methylation of the 5-position of cytosine (mC) have essential roles in regulating gene expression and maintaining cellular identity. Recently, TET1 was found to hydroxylate the methyl gr...

    Kristine Williams, Jesper Christensen, Marianne Terndrup Pedersen… in Nature (2011)

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    Article

    JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells

    Polycomb proteins have a key role in regulating the expression of genes essential for development, differentiation and maintenance of cell fates. Here, Polycomb repressive complex 2 (PRC2) is shown to form a c...

    Diego Pasini, Paul A. C. Cloos, Julian Walfridsson, Linda Olsson… in Nature (2010)

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    Article

    UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development

    Two human JmjC-domain-containing enzymes are shown to catalyse demethylation of histone H3K27me3, a histone modification mediated by polycomb proteins and associated with stem cell maintenance and differentiation

    Karl Agger, Paul A. C. Cloos, Jesper Christensen, Diego Pasini, Simon Rose… in Nature (2007)

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    Article

    The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3

    Two papers in this issue identify enzymes capable of demethylating a trimethyl group from the Lys 9 residue of histone H3 — a 'mark' required for the establishment of heterochromatin and previously considered ...

    Paul A. C. Cloos, Jesper Christensen, Karl Agger, Alessio Maiolica… in Nature (2006)

  5. No Access

    Article

    Post-Translational Modifications of Proteins: Implications for Aging, Antigen Recognition, and Autoimmunity

    Proteins are complex organic molecules susceptible to numerous post-translational modifications occurring spontaneously during aging or as a consequence of physiologic or pathologic processes. Antigenicity and...

    Paul A. C. Cloos, Stephan Christgau in Biogerontology (2004)

  6. No Access

    Article

    Age-related de-phosporylation of proteins in dentin: A biological tool for assessment of protein age

    Mature tooth dentin has essentially no metabolic activity, and thus post-translational modifications accumulate with aging in this tissue. In the present paper, we have studied age-related covalent changes of ...

    Paul A.C. Cloos, Arne L. Jensen in Biogerontology (2000)