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  1. Article

    Open Access

    The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes

    Epigenetic regulators are frequently mutated in hematological malignancies including acute myeloid leukemia (AML). Thus, the identification and characterization of novel epigenetic drivers affecting AML biolog...

    Mette Louise Trempenau, Mikkel Bruhn Schuster, Sachin Pundhir… in Leukemia (2023)

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  2. Article

    Open Access

    The histone chaperone NAP1L3 is required for haematopoietic stem cell maintenance and differentiation

    Nucleosome assembly proteins (NAPs) are histone chaperones with an important role in chromatin structure and epigenetic regulation of gene expression. We find that high gene expression levels of mouse Nap1l3 are ...

    Yaser Heshmati, Shabnam Kharazi, Gözde Türköz, David Chang… in Scientific Reports (2018)

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    Article

    Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies

    The therapeutic response of acute myelogenous leukemia to the nucleoside analog ara-C is controlled by SAMHD1, an enzyme that hydrolyzes the activemetabolite ara-CTP.

    Nikolas Herold, Sean G Rudd, Linda Ljungblad, Kumar Sanjiv… in Nature Medicine (2017)

  4. No Access

    Article

    JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells

    Polycomb proteins have a key role in regulating the expression of genes essential for development, differentiation and maintenance of cell fates. Here, Polycomb repressive complex 2 (PRC2) is shown to form a c...

    Diego Pasini, Paul A. C. Cloos, Julian Walfridsson, Linda Olsson… in Nature (2010)