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Article
Open AccessMulti-label transcriptional classification of colorectal cancer reflects tumor cell population heterogeneity
Transcriptional classification has been used to stratify colorectal cancer (CRC) into molecular subtypes with distinct biological and clinical features. However, it is not clear whether such subtypes represent...
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Article
Open AccessDissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity
The Polycomb repressive complexes PRC1 and PRC2 act non-redundantly at target genes to maintain transcriptional programs and ensure cellular identity. PRC2 methylates lysine 27 on histone H3 (H3K27me), while P...
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Article
Open AccessFocal adhesion kinase depletion reduces human hepatocellular carcinoma growth by repressing enhancer of zeste homolog 2
Hepatocellular carcinoma (HCC) is the most common type of liver cancer in humans. The focal adhesion tyrosine kinase (FAK) is often over-expressed in human HCC and FAK inhibition may reduce HCC cell invasivene...
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Article
Open AccessEpiMINE, a computational program for mining epigenomic data
In epigenetic research, both the increasing ease of high-throughput sequencing and a greater interest in genome-wide studies have resulted in an exponential flooding of epigenetic-related data in public domai...
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Protocol
Map** the Function of Polycomb Proteins
Polycomb group (PcG) proteins are master regulators of proliferation and development that play essential roles in human pathologies including cancers. PcGs act as gatekeepers of cellular identity, maintaining ...
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Article
Open AccessPolycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication
The ability of PRC1 and PRC2 to promote proliferation is a main feature that links polycomb (PcG) activity to cancer. PcGs silence the expression of the tumour suppressor locus Ink4a/Arf, whose products positivel...
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Article
Epigenetic methylations and their connections with metabolism
Metabolic pathways play fundamental roles in several processes that regulate cell physiology and adaptation to environmental changes. Altered metabolic pathways predispose to several different pathologies rang...
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Article
Open AccessChromatin regulated interchange between polycomb repressive complex 2 (PRC2)-Ezh2 and PRC2-Ezh1 complexes controls myogenin activation in skeletal muscle cells
Polycomb group (PcG) genes code for chromatin multiprotein complexes that are responsible for maintaining gene silencing of transcriptional programs during differentiation and in adult tissues. Despite the lar...
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Article
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
Polycomb proteins have a key role in regulating the expression of genes essential for development, differentiation and maintenance of cell fates. Here, Polycomb repressive complex 2 (PRC2) is shown to form a c...
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Article
Erratum: A model for transmission of the H3K27me3 epigenetic mark
Nature Cell Biol. 10, 1291–1300 (2008); published online 19 October 2008; corrected after print 28 October 2008 In the version of this article initially published, the order of the labels siRNA cyclophilin B a...
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Article
A model for transmission of the H3K27me3 epigenetic mark
The chromatin mark H3K27me3 is transmitted during cell division by recruitment and binding of the PRC2 complex, which maintains the mark and leads to methylation of H3K27 on newly incorporated histones.
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Article
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development
Two human JmjC-domain-containing enzymes are shown to catalyse demethylation of histone H3K27me3, a histone modification mediated by polycomb proteins and associated with stem cell maintenance and differentiation
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Article
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer
Recent experiments have demonstrated that the Polycomb group (PcG) gene EZH2 is highly expressed in metastatic prostate cancer and in lymphomas. EZH2 is a component of the PRC2 histone methyltransferase complex, ...
