-
Article
Author Correction: Chronic cardiovascular–kidney disorder: a new conceptual framework
-
Article
Chronic cardiovascular–kidney disorder: a new conceptual framework
The current nomenclature for cardiorenal syndrome is problematic owing to its chronological approach and the systemic nature of some of the subtypes. We suggest adoption of a new concept, chronic cardiovascula...
-
Article
Open AccessSepsis-associated acute kidney injury: recent advances in enrichment strategies, sub-phenoty** and clinical trials
Acute kidney injury (AKI) often complicates sepsis and is associated with high morbidity and mortality. In recent years, several important clinical trials have improved our understanding of sepsis-associated A...
-
Article
Open AccessBudget Impact Analysis of Expanding Gliflozin Coverage in the CKD Population: A French Perspective
Gliflozins have historically been indicated for type 2 diabetes in France. However, their efficacy has recently been demonstrated in heart failure and chronic kidney disease (CKD), with positive recommendation...
-
Article
Open AccessEffect on cardiac function among patients with type 2 diabetes following high-dose mineralocorticoid receptor antagonist using echocardiography; data from the MIRAD randomized clinical trial
Early heart failure prevention is central in patients with type 2 diabetes, and mineralocorticoid receptor antagonists (MRAs) have shown to improve prognosis. We investigated the effect of high-dose MRA, epler...
-
Article
Validation of the MEDIA echo score for the prognosis of heart failure with preserved ejection fraction
There is currently no widely used prognostic score in heart failure (HF) with preserved ejection fraction (HFpEF). The MEDIA echo score, including four variables (pulmonary arterial systolic pressure > 40 mmH...
-
Article
Early and late renal function changes with spironolactone in patients at risk of develo** heart failure: findings from the HOMAGE trial
-
Article
Head-to-head comparison of diagnostic scores for acute heart failure in the emergency department: results from the PARADISE cohort
BREST and PREDICA scores have recently emerged for the diagnosis of acute heart failure (AHF) in the emergency department (ED). This study aimed to perform a head-to-head comparison in a large contemporary coh...
-
Article
Open AccessSerum markers of fibrosis, cardiovascular and all-cause mortality in hemodialysis patients: the AURORA trial
Biomarkers of fibrosis are associated with outcome in several cardiovascular diseases. However, their relevance to chronic kidney disease and dialysis is uncertain, as it remains unclear how the kidneys and th...
-
Article
Weight changes in heart failure with preserved ejection fraction: findings from TOPCAT
Weight loss has been associated with poor outcomes in patients with heart failure (HF). However, few data are available for patients with heart failure with preserved ejection fraction (HFpEF). The impact of w...
-
Article
Serum sodium and eplerenone use in patients with a myocardial infarction and left ventricular dysfunction or heart failure: insights from the EPHESUS trial
Sodium changes are common in myocardial infarction (MI) complicated with left ventricular systolic dysfunction (LVSD) and/or heart failure (HF). Sodium handling is fine-tuned in the distal nephron, were eplere...
-
Article
Correction to: Hyperkalemia in Chronic Kidney Disease in the New Era of Kidney Protection Therapies
-
Article
Open AccessBody weight changes in patients with type 2 diabetes and a recent acute coronary syndrome: an analysis from the EXAMINE trial
Patients with type 2 diabetes (T2D) may experience frequent body weight changes over time. The prognostic impact of these weight changes (gains or losses) requires further study.
-
Article
Open AccessStandardised Outcomes in Nephrology – Chronic Kidney Disease (SONG-CKD): a protocol for establishing a core outcome set for adults with chronic kidney disease who do not require kidney replacement therapy
Globally, over 1.2 million people die from chronic kidney disease (CKD) every year. Patients with CKD are up to 10 times more likely to die prematurely than progress to kidney failure requiring kidney replacem...
-
Article
Open AccessSafety and Tolerability of the Potassium Binder Patiromer From a Global Pharmacovigilance Database Collected Over 4 Years Compared with Data from the Clinical Trial Program
The availability of the sodium-free potassium binder patiromer opens new opportunities for hyperkalemia management.
-
Article
Hyperkalemia in Chronic Kidney Disease in the New Era of Kidney Protection Therapies
Despite recent therapeutic advances, chronic kidney disease (CKD) is one of the fastest growing global causes of death. This illustrates limitations of current therapeutic approaches and, potentially, unidenti...
-
Article
Open AccessProteomic mechanistic profile of patients with diabetes at risk of develo** heart failure: insights from the HOMAGE trial
Patients with diabetes mellitus (DM) are at increased risk of develo** heart failure (HF). The “Heart OMics in AGEing” (HOMAGE) trial suggested that spironolactone had beneficial effect on fibrosis and cardi...
-
Article
Association between right-sided cardiac function and ultrasound-based pulmonary congestion on acutely decompensated heart failure: findings from a pooled analysis of four cohort studies
Right ventricular (RV) dysfunction and RV–pulmonary artery (PA) uncoupling are associated with the development of pulmonary congestion during exercise. However, there is limited information regarding the assoc...
-
Article
Diuretic therapy as prognostic enrichment factor for clinical trials in patients with heart failure with reduced ejection fraction
Loop diuretics are the mainstay of congestion treatment in patients with heart failure (HF). We assessed the association between baseline loop diuretic use and outcome. We also compared the increment in risk r...
-
Article
Estimated plasma volume status in heart failure: clinical implications and future directions
Congestion is one of the main predictors of poor outcome in patients with heart failure (HF). Assessing and monitoring congestion is essential for optimizing HF therapy. Among the various available methods, se...
