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Open AccessIncidence of acute kidney injury and attributive mortality in acute respiratory distress syndrome randomized trials
The development of acute kidney injury (AKI) after the acute respiratory distress syndrome (ARDS) reduces the chance of organ recovery and survival. The purpose of this study was to examine the AKI rate and at...
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Open AccessCorrection: Mild increases in plasma creatinine after intermediate to high-risk abdominal surgery are associated with long-term renal injury
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Using diuretic therapy in the critically ill patient
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Serial lactate measurements to guide resuscitation: more evidence not to?
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Open AccessSepsis-associated acute kidney injury: recent advances in enrichment strategies, sub-phenoty** and clinical trials
Acute kidney injury (AKI) often complicates sepsis and is associated with high morbidity and mortality. In recent years, several important clinical trials have improved our understanding of sepsis-associated A...
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Acute kidney injury in patients with burns
Burn injury is associated with a high risk of acute kidney injury (AKI) with a prevalence of AKI among patients with burns of 9–50%. Despite an improvement in burn injury survival in the past decade, AKI in pa...
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Open AccessAn international RAND/UCLA expert panel to determine the optimal diagnosis and management of burn inhalation injury
Burn inhalation injury (BII) is a major cause of burn-related mortality and morbidity. Despite published practice guidelines, no consensus exists for the best strategies regarding diagnosis and management of B...
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Open AccessThe alternative renin–angiotensin system in critically ill patients: pathophysiology and therapeutic implications
The renin–angiotensin system (RAS) plays a crucial role in regulating blood pressure and the cardio-renal system. The classical RAS, mainly mediated by angiotensin I, angiotensin-converting enzyme, and angiote...
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Subclinical and clinical acute kidney injury share similar urinary peptide signatures and prognosis
Acute kidney injury (AKI) is a frequent and severe condition in intensive care units (ICUs). In 2020, the Acute Dialysis Quality Initiative (ADQI) group proposed a new stage of AKI, referred to as stage 1S, wh...
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Tackling sepsis-associated acute kidney injury using routinely collected data
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Open AccessAdjunctive vasopressors in distributive shock: How soon is early?
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Open AccessCould Repeated Cardio-Renal Injury Trigger Late Cardiovascular Sequelae in Extreme Endurance Athletes?
Regular exercise confers multifaceted and well-established health benefits. Yet, transient and asymptomatic increases in markers of cardio-renal injury are commonly observed in ultra-endurance athletes during ...
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Differences in HADS and SF-36 scores 1 year after critical illness in COVID-19 patients
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Open AccessCapillary refill time for the management of acute circulatory failure: a survey among pediatric and adult intensivists
Recent studies have shown the prognostic value of capillary refill time (CRT) and suggested that resuscitation management guided by CRT may reduce morbidity and mortality in patients with septic shock. However...
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Correction to: Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial
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Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial
Duration of antibiotic therapy for ventilator-associated pneumonia (VAP) due to non-fermenting Gram-negative bacilli (NF-GNB), including Pseudomonas aeruginosa (PA) remains uncertain. We aimed to assess the non-i...
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Ten tips to optimize vasopressors use in the critically ill patient with hypotension
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Pathophysiology of COVID-19-associated acute kidney injury
Although respiratory failure and hypoxaemia are the main manifestations of COVID-19, kidney involvement is also common. Available evidence supports a number of potential pathophysiological pathways through whi...
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Ketamine-induced cholangiopathy in ARDS patients
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Open AccessAcute kidney injury in the critically ill: an updated review on pathophysiology and management
Acute kidney injury (AKI) is now recognized as a heterogeneous syndrome that not only affects acute morbidity and mortality, but also a patient’s long-term prognosis. In this narrative review, an update on var...