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Article
Open AccessWhat is the value of reactive case detection in malaria control? A case-study in India and a systematic review
Reactive case detection (RCD) for malaria is a strategy to identify additional malaria infections in areas of low malaria transmission and can complement passive surveillance. This study describes experiences ...
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Article
Open AccessChloroquine efficacy studies confirm drug susceptibility of Plasmodium vivax in Chennai, India
Assessing the Plasmodium vivax burden in India is complicated by the potential threat of an emerging chloroquine (CQ) resistant parasite population from neighbouring countries in Southeast Asia. Chennai, the capi...
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Article
Open AccessA call to arms: on refining Plasmodium vivax microsatellite marker panels for comparing global diversity
Microsatellite (MS) markers have become an important tool for studying the population diversity, evolutionary history and multiplicity of infection (MOI) of malaria parasite infections. MS are typically select...
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Article
Open AccessThe complexities of malaria disease manifestations with a focus on asymptomatic malaria
Malaria is a serious parasitic disease in the develo** world, causing high morbidity and mortality. The pathogenesis of malaria is complex, and the clinical presentation of disease ranges from severe and com...
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Article
Open AccessMutant pfcrt "SVMNT" haplotype and wild type pfmdr1 "N86" are endemic in Plasmodium vivax dominated areas of India under high chloroquine exposure
Chloroquine resistance (CQR) phenotype in Plasmodium falciparum is associated with mutations in pfcrt and pfmdr-1 genes. Mutations at amino acid position 72-76 of pfcrt gene, here defined as pfcrt haplotype are a...
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Article
Open AccessSexual recombination is a signature of a persisting malaria epidemic in Peru
The aim of this study was to consider the impact that multi-clone, complex infections have on a parasite population structure in a low transmission setting. In general, complexity of infection (minimum number ...
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Article
Open AccessThe Plasmodium falciparum merozoite surface protein-1 19 KD antibody response in the Peruvian Amazon predominantly targets the non-allele specific, shared sites of this antigen
Plasmodium falciparum re-emerged in Iquitos, Peru in 1994 and is now hypoendemic (< 0.5 infections/person/year). Purportedly non-immune individuals with discrete (non-overlap**) P. falciparum infections can be ...