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Article
Sequence analysis of two nuclear encoded subunits (10 and 51 kDa) of mitochondrial complex I in Parkinson disease
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Article
Neuronal damage of the substantia nigra in HIV-1 infected brains
Extrapyramidal motor disorders are frequently noted in HIV-1-infected patients. In the present study, the substantia nigra was analyzed morphometrically to detect neuronal changes which might contribute to th...
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Article
The α1-antichymotrypsin A-allele in German Parkinson disease patients
An increased frequency of the A-allele of the α1-antichymotrypsin (ACT) gene has been recently described in Japanese patients suffering from Parkinson disease (PD). In the present study, we have analyzed 62 Germ...
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Article
Histopathology and APOE genotype of the first Alzheimer disease patient, Auguste D.
Alois Alzheimer published two papers on the disease which was named after him by Emil Kraepelin in 1910. Each of these papers contains clinical and pathological data on a patient Alzheimer had seen at the hos...
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Article
Rediscovery of the case described by Alois Alzheimer in 1911: historical, histological and molecular genetic analysis
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Chapter and Conference Paper
Untersuchungen zum Apolipoprotein E-Genotyp an histologisch gesicherten Fällen von Morbus Alzheimer
Die Alzheimersche Krankheit ist die häufigste Ursache der senilen Demenz. Sie betrifft etwa 5% bis 20% der 65–80jährigen und ist derzeit nach Herzerkrankungen, Malignomen und Apoplexie die vierthäufigste Todes...
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Article
Apolipoprotein E genotype and neuropathological phenotype in two members of a German family with chromosome 14-linked early onset Alzheimer's disease
Molecular genetic analysis was performed in two autopsy-confirmed cases of early-onset Alzheimer's disease belonging to a large German pedigree [FAD2, according to the nomenclature of St. George-Hyslop, et al....
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Article
Abstracts
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Chapter and Conference Paper
Morphometrische Aspekte cerebraler Asymmetrien
Unter Anwendung stereologischer Verfahren wird untersucht, ob auf makroskopischer Ebene, morphologische Unterschiede im menschlichen Gehirn zwischen der linken und rechten Hemisphäre bestehen.
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Chapter and Conference Paper
Morphometrische Aspekte bei HIV-1 Infektion
Die Veränderungen der unterschiedlichen Zellsysteme im Gehirn von HIV-1 infizierten, verstorbenen Patienten wurden mit morphometrischen Methoden untersucht.
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Article
Distribution of prion protein in German patients with Creutzfeldt-Jakob disease is different from that in Japanese patients
We investigated the distribution of prion protein (PrP) in 14 German patients with sporadic Creutzfeldt-Jakob disease (CJD) and compared it with that observed in Japanese patients. Immunohistochemical study re...
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Article
Synaptic strip** in the human facial nucleus
An autopsy case of severe peripheral facial nerve paresis with disconnection of synapses from facial motor neurons is reported. A 77-year-old man presented with left-sided otitis media and subsequent developme...
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Article
Diffuse deposition of immunohistochemically labeled prion protein in the granular layer of the cerebellum in a patient with Creutzfeldt-Jakob disease
Amyloid plaques in Creutzfeldt-Jakob discase, kuru, and Gerstmann-Sträussler-Scheinker syndrome are known to contain an abnormal isoform of a cellular protein, the prion protein (PrP). The prion protein in its...
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Article
Striatopallidonigral degeneration in Pick's disease: a clinicopathological study of 41 cases
The frequency and degree of stiatopallidonigral (SPN) degeneration were examined in 41 autopsy cases of Pick's disease. Based on the degree of SPN degeneration, these cases were arranged into four groups: 1) g...
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Chapter
A New Experimental Model of Sinus Vein Thrombosis
Several experimental attempts have failed to induce thrombosis of the cerebral sinus using methods such as ligation, coagulation, or injection of thrombogenic material [1–3]. Ligation and injection of lard-oil...
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Chapter and Conference Paper
Changes of Intracranial Pressure in a Rat Meningitis Model
Brain edema formation, raised intracranial pressure (ICP) and alterations of the cerebral blood circulation are thought to be of great importance for the outcome of bacterial meningitis (Dodge and Swartz 1965,...
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Article
Growth inhibition of experimental glioma grafts by monoclonal antibody treatment
The effects of 14AC1 monoclonal antibody (McAb) on 79FR-G-41 rat glioma cells in vitro, on the formation of metastases in lung by antibody coated glioma cells, and on the growth of glioma grafts in BALB/c-nu/n...
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Chapter
Plötzlicher Tod nach Hirntumorentfernung
Im Februar 1984 war bei dem fast 35 Jahre alten Patienten nach einer längeren Anamnese ein zystischer Tumor in der rechten Kleinhirnhemisphäre mit Verdrängung des 4. Ventrikels festgestellt und am 22. 02. 1984...
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Article
Localization of experimental glioma grafts by means of iodinated monoclonal antibodies and radionuclide imaging
Purified McAbs (14AC1) of IgG2a isotype raised against an experimental rat glioma (79 FR-G-41) were labeled with Na131I and used for in vivo imaging of glioma grafts by external body seintigraphy. Normal mouse131
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Chapter
Diagnostik und Verlauf von gefäßentzündlich bedingten Polyneuropathien
In der Erstbeschreibung der bekanntesten Gefäßentzündung, der Periarteriitis nodosa, wiesen bereits Kussmaul u. Maier (1866) auf die begleitende, progrediente Polyneuropathie hin. Durch umfassende klinisch-pathol...
