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Article
Open AccessReal-life instability in ADHD from young to middle adulthood: a nationwide register-based study of social and occupational problems
Studies using self-reports indicate that individuals with ADHD are at increased risk for functional impairments in social and occupational settings, but evidence around real-life instability remains limited. I...
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Article
Open AccessChronic pain conditions and risk of suicidal behavior: a 10-year longitudinal co-twin control study
Understanding the relationship between chronic pain conditions and suicidal behavior—suicide attempt, other intentional self-harm, and death by suicide—is imperative for suicide prevention efforts. Although ch...
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Article
Open AccessAntidepressant prescription patterns and CNS polypharmacy with antidepressants among children, adolescents, and young adults: a population-based study in Sweden
This study examines trends in antidepressant drug dispensations among young people aged 0–24 years in Sweden during the period 2006–2013, as well as prescription patterns and central nervous system (CNS) polyp...
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Article
A total-population multigenerational family clustering study of autoimmune diseases in obsessive–compulsive disorder and Tourette’s/chronic tic disorders
The association between obsessive–compulsive disorder (OCD) and Tourette’s/chronic tic disorders (TD/CTD) with autoimmune diseases (ADs) is uncertain. In this nationwide study, we sought to clarify the pattern...
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Article
Open AccessPerinatal risk factors in Tourette’s and chronic tic disorders: a total population sibling comparison study
Adverse perinatal events may increase the risk of Tourette’s and chronic tic disorders (TD/CTD), but previous studies have been unable to control for unmeasured environmental and genetic confounding. We aimed ...
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Article
Open AccessThe familial co-aggregation of ASD and ADHD: a register-based cohort study
Autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD) frequently co-occur. The presence of a genetic link between ASD and ADHD symptoms is supported by twin studies, but the genet...
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Article
Open AccessSuicide in obsessive–compulsive disorder: a population-based study of 36 788 Swedish patients
The risk of death by suicide in individuals with obsessive–compulsive disorder (OCD) is largely unknown. Previous studies have been small and methodologically flawed. We analyzed data from the Swedish national...
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Article
Erratum: Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder
Correction to: Molecular Psychiatry advance online publication, 27 October 2015; doi:10.1038/mp.2015.165 The list of authors in the HTML version of the article incorrectly included all the members of the Inter...
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Open AccessEvidence for genetic heterogeneity between clinical subtypes of bipolar disorder
We performed a genome-wide association study of 6447 bipolar disorder (BD) cases and 12 639 controls from the International Cohort Collection for Bipolar Disorder (ICCBD). Meta-analysis was performed with prio...
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Article
Open AccessA genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder
Elevated cerebrospinal fluid (CSF) levels of the glia-derived N-methyl-D-aspartic acid receptor antagonist kynurenic acid (KYNA) have consistently been implicated in schizophrenia and bipolar disorder. Here, we c...
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Article
Open AccessGenome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder
Lithium is the mainstay prophylactic treatment for bipolar disorder (BD), but treatment response varies considerably across individuals. Patients who respond well to lithium treatment might represent a relativ...
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Article
Contribution of non-genetic factors to dopamine and serotonin receptor availability in the adult human brain
The dopamine (DA) and serotonin (5-HT) neurotransmission systems are of fundamental importance for normal brain function and serve as targets for treatment of major neuropsychiatric disorders. Despite central ...
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Article
Antisocial behavior and polymorphisms in the oxytocin receptor gene: findings in two independent samples
The quantitative genetic contribution to antisocial behavior is well established, but few, if any, genetic variants are established as risk factors. Emerging evidence suggests that the neuropeptide oxytocin (O...
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Article
Common psychiatric disorders share the same genetic origin: a multivariate sibling study of the Swedish population
Recent studies have shown that different mental-health problems appear to be partly influenced by the same set of genes, which can be summarized by a general genetic factor. To date, such studies have relied o...
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Article
Open AccessSchizophrenia and subsequent neighborhood deprivation: revisiting the social drift hypothesis using population, twin and molecular genetic data
Neighborhood influences in the etiology of schizophrenia have been emphasized in a number of systematic reviews, but causality remains uncertain. To test the social drift hypothesis, we used three complementar...
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Article
A genome-wide association study of anorexia nervosa
Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded si...
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Article
Shared genetic influence of BMI, physical activity and type 2 diabetes: a twin study
The aim of this study was to examine the long-term associations of BMI and physical activity with type 2 diabetes, and to estimate shared genetic components of these traits.
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Article
Genetic Innovation and Stability in Externalizing Problem Behavior Across Development: A Multi-Informant Twin Study
The use of cross-informant ratings in previous longitudinal studies on externalizing behavior may have obscured the presence of continuity of genetic risk. The current study included latent factors representin...
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Article
Incidence of disability pension and associations with socio-demographic factors in a Swedish twin cohort
The incidence of disability pension (DP), especially due to mental diagnoses, has increased in many countries, but knowledge of socio-demographic risk factors for DP is limited. Further, the influences of gene...
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Article
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder
Schizophrenia (SCZ) and bipolar disorder (BD) are highly heritable psychiatric disorders with overlap** susceptibility loci and symptomatology. We conducted a genome-wide association study (GWAS) of these di...
