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  1. Article

    Open Access

    Therapygenetics in mindfulness-based cognitive therapy: do genes have an impact on therapy-induced change in real-life positive affective experiences?

    Positive affect (PA) has an important role in resilience against depression and has been shown to increase with mindfulness-based cognitive therapy (MBCT). To elucidate the underlying mechanisms of change in P...

    J M Bakker, R Lieverse, C Menne-Lothmann, W Viechtbauer… in Translational Psychiatry (2014)

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  2. No Access

    Article

    Genetic Innovation and Stability in Externalizing Problem Behavior Across Development: A Multi-Informant Twin Study

    The use of cross-informant ratings in previous longitudinal studies on externalizing behavior may have obscured the presence of continuity of genetic risk. The current study included latent factors representin...

    M. Wichers, C. Gardner, H. H. Maes, P. Lichtenstein, H. Larsson… in Behavior Genetics (2013)

  3. No Access

    Article

    Peri-operative glucocorticoid replacement therapy in transsphenoidal pituitary adenoma surgery: a prospective controlled study

    Background. We set out to prospectively study the peri-operative changes of the hypothalamic-pituitary-adrenal axis (HPA), and to test the hypothesis that the peri-operative corticoid replacement regimen used at ...

    R. A. Kristof, M. Wichers, D. Haun, L. Redel, D. Klingmüller… in Acta Neurochirurgica (2008)

  4. No Access

    Article

    Endocrinological Outcome Following First Time Transsphenoidal Surgery for GH-, ACTH-, and PRL-Secreting Pituitary Adenomas

    To study remission rates and pituitary functions following transsphenoidal surgery of newly diagnosed GH-, ACTH-, and PRL-secreting pituitary adenomas.

    R. A. Kristof, J. Schramm, L. Redel, G. Neuloh, M. Wichers… in Acta Neurochirurgica (2002)

  5. No Access

    Article

    Somatotropic axis dysfunction in critically ill patients: altered response to growth hormone-releasing hormone

    Wachstumshormon (GH) hat neben anabolen Wirkungen auch immunmodulatorische Effekte. Der Einfluss von Wachstumshormon auf das Immunsystem wird kontrovers diskutiert. In der vorliegenden Studie wird die Funktio...

    S. Schroeder, W. Springer, M. Hashemian, M. Wichers… in Intensivmedizin und Notfallmedizin (2001)

  6. No Access

    Article

    X-linked adrenomyeloneuropathy associated with 14 novel ALD-gene mutations: no correlation between type of mutation and age of onset

    Adrenomyeloneuropathy (AMN) represents a milder form of X-linked adrenoleukodystrophy (ALD), the most frequent peroxisomal disorder. The disease is characterised by an abnormal accumulation of saturated, very ...

    M. Wichers, W. Köhler, W. Brennemann, V. Boese, P. Sokolowski… in Human Genetics (1999)

  7. No Access

    Article

    Pituitary apoplexy with spontaneous cure of acromegaly and its possible relation to Gd-DTPA-administration

    A case of pituitary apoplexy occurring after Gd-DTPA-administration for contrast enhanced MRI in a patient with an hGH-producing macro-adenoma is presented. Within days the initially increased hGH level fell t...

    M. Wichers, R. A. Kristof, W. Springer, J. Schramm, D. Klingmüller in Acta Neurochirurgica (1997)

  8. No Access

    Chapter and Conference Paper

    Resistenzentwicklung von HIV: Biologischer Test oder Sequenzanalyse des Polymerase-Gens?

    Alle z.Zt. zugelassenen antiretroviralen Chemotherapeutika sind nukleosidische Polymerase-Hemmer. Als Nukleosid-Analoge müssen sie von zellulären Kinasen phosphoryliert werden, um dann an die virale Polymerase...

    M. Wichers, A. Mayer, R. Rolf, R. Kaiser… in 25. Hämophilie-Symposion Hamburg 1994 (1996)

  9. No Access

    Chapter and Conference Paper

    Vergleich der biologischen Resistenzbestimmung von HIV-Stämmen gegenüber Azidothymidin (AZT) mit der Sequenzanalyse des Polymerasegens

    Hauptangriffspunkt der antiviralen Chemotherapie der HIV-Infektion ist bis heute die reverse Transkriptase (RT), ein Teilprodukt des HIV Polymerasegens, mit dem Ziel, durch die Hemmung der reversen Transkripti...

    M. Wichers, A. Ackermann, A. Meyer, R. Rolf, R. Kaiser… in 24. Hämophilie-Symposion (1994)