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  1. No Access

    Chapter

    Genetic Aspects of Cell Line Development from a Synthetic Biology Perspective

    Animal cells can be regarded as factories for the production of relevant proteins. The advances described in this chapter towards the development of cell lines with higher productivity capacities, certain meta...

    L. Botezatu, S. Sievers, L. Gama-Norton… in Genomics and Systems Biology of Mammalian … (2012)

  2. No Access

    Article

    A new PG13-based packaging cell line for stable production of clinical-grade self-inactivating γ-retroviral vectors using targeted integration

    The clinical application of self-inactivating (SIN) retroviral vectors has been hampered by the lack of reliable and efficient vector production technologies. To enable production of SIN γ-retroviral vectors f...

    R Loew, Y Meyer, K Kuehlcke, L Gama-Norton, D Wirth, H Hauser, S Stein… in Gene Therapy (2010)

  3. No Access

    Chapter

    Defeating Randomness – Targeted Integration as a Boost for Biotechnology

    Genetic modification of mammalian cells is a prerequisite for the production of recombinant proteins, virus like particles, and viruses. For most applications long-term stability of such modifications is neede...

    L. Gama-Norton, P. Riemer, U. Sandhu, K. Nehlsen, R. Schucht… in Cell Line Development (2009)