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Article
Mitochondrial Dynamics and Metabolic Remodeling in a Xenograft of Human iPSC-Derived Neural Precursors
Regulation of mitochondrial functions impacts on neuronal differentiation and maturation. Studying these processes is of both fundamental and practical importance for regenerative neurobiology. This work was a...
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Article
Low-Rank Approximation Algorithms for Matrix Completion with Random Sampling
The possibility of accelerating a projection algorithm onto dominant singular spaces in the problem of recovering a low-rank matrix from a small number of its entries is explored. The underlying idea is to rep...
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Article
Effect of Isomorphic Impurities on the Elastic Conductivity of Chiral Carbon Nanotubes
A theoretical study is made of the piezoresistive properties of chiral carbon nanotubes with different types of conduction, both ideal and doped with substitutional point defects at different concentrations, u...
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Article
“Necessity Is the Mother of Invention” or Inexpensive, Reliable, and Reproducible Protocol for Generating Organoids
Organoids are three-dimensional (3D) cell cultures that replicate some of the key features of morphology, spatial architecture, and functions of a particular organ. Organoids can be generated from both adult a...
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Article
Pluripotent Stem Cells for Modelling and Cell Therapy of Parkinson’s Disease
Studying pathogenesis of neurodegenerative diseases, including Parkinson’s disease (PD), requires adequate disease models. The available patient’s material is limited to biological fluids and post mortem brain sa...
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Article
The Transcriptional Changes of trim Genes Associated with Parkinson’s Disease on a Model of Human Induced Pluripotent Stem Cells
Over the last few years, in vitro models, based on patient-derived induced pluripotent stem cells (iPSCs), have received considerable attention for modeling different neurodegenerative disorders. Using this mo...
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Article
Investigation of the effect of α-melanocyte-stimulating hormone on proliferation and early stages of differentiation of human induced pluripotent stem cells
We have studied the influence of α-melanocyte-stimulating hormone (α-MSH) on proliferation and early stages of differentiation of human induced pluripotent stem cells (iPSc). We have demonstrated that α-MSH re...
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Article
Genetic cell reprogramming: A new technology for basic research and applied usage
Gene function disclosure and the development of modern technologies of genetic manipulations offered the possibility of genetic reprogramming application to alter cell specialization. With the involvement of a...
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Article
Strain-induced changes in the band gap of doped carbon nanotubes
The results of a theoretical research into the band gap of strained doped carbon nanotubes of two structural modifications of the “armchair” and “zigzag” types are described. The electronic states in the doped...
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Article
The morphofunctional properties of induced pluripotent stem cells derived from human skin fibroblasts and differentiated to dopaminergic neurons
A dopamine deficit in the nigrostriatal system is the key neurotransmitter impairment that is responsible for the principal clinical manifestations of Parkinson’s disease. Modern therapeutic methods allow one ...
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Article
Block tensor conjugate gradient-type method for Rayleigh quotient minimization in two-dimensional case
A method for solving a partial algebraic eigenvalues problem is constructed. It exploits tensor structure of eigenvectors in two-dimensional case. For a symmetric matrix represented in tensor format, the metho...
