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Article
Open AccessSex and disease severity-based analysis of steroid hormones in ME/CFS
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease characterized by persistent fatigue and decreased daily activity following physical and/or cognitive exertion. While ME/CFS...
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Article
Open AccessAntibody selection strategies and their impact in predicting clinical malaria based on multi-sera data
Nowadays, the chance of discovering the best antibody candidates for predicting clinical malaria has notably increased due to the availability of multi-sera data. The analysis of these data is typically divide...
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Article
Open AccessSero-epidemiological study of arbovirus infection following the 2015–2016 Zika virus outbreak in Cabo Verde
In November 2015, cases of Zika virus infection were recorded in Cabo Verde (Africa), originating from Brazil. The outbreak subsided after seven months with 7580 suspected cases. We performed a serological sur...
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Chapter and Conference Paper
Impact of Misclassification and Imperfect Serological Tests in Association Analyses of ME/CFS Applied to COVID-19 Data
The diagnosis of ME/CFS is problematic due to the absence of a disease specific biomarker. As such, it is conducted under uncertainty using symptom-based criteria and the exclusion of known diseases. The possi...
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Chapter and Conference Paper
Identification of Antibody Responses Predictive of Protection Against Clinical Malaria
Statistical pipelines have been proposed to discover antibody responses associated with protection against clinical malaria. However, these often produce inconsistent results due to the failure of the statisti...
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Chapter and Conference Paper
How to Increase the Visibility of Statisticians in the Modern World of Dataism?
In the view of the historian Yuval Noah Harari, current human thought can be characterized by a deep belief in data, whether big or small, as the main vehicle to understand and control the world. This belief i...
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Article
Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
A Correction to this paper has been published: https://doi.org/10.1038/s41588-021-00832-z.
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Article
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to ~1.3 million participants, we discovered 106 new BP-associated g...
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Article
Open AccessSurveillance of Aedes aegypti populations in the city of Praia, Cape Verde: Zika virus infection, insecticide resistance and genetic diversity
Aedes spp. are responsible for the transmission of many arboviruses, which contribute to rising human morbidity and mortality worldwide. The Aedes aegypti mosquito is a main vector for chikungunya, dengue and yel...
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Article
Open AccessQuality control of multiplex antibody detection in samples from large-scale surveys: the example of malaria in Haiti
Measuring antimalarial antibodies can estimate transmission in a population. To compare outputs, standardized laboratory testing is required. Here we describe the in-country establishment and quality control (...
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Article
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 no...
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Article
Open AccessEvaluation of the humoral immune response induced by vaccination for canine distemper and parvovirus: a pilot study
Canine Distemper Virus (CDV) and Canine Parvovirus (CPV) lead to infections with high mortality rates in dogs. These viruses affect unvaccinated dogs or dogs with incomplete vaccination protocols. Vaccination ...
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Article
Open AccessSerology reflects a decline in the prevalence of trachoma in two regions of The Gambia
Trachoma is caused by Chlamydia trachomatis (Ct). It is targeted for global elimination as a public health problem. In 2014, a population-based cross-sectional study was performed in two previously trachoma-endem...
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Article
Open AccessPlasmodium falciparum parasites with histidine-rich protein 2 (pfhrp2) and pfhrp3 gene deletions in two endemic regions of Kenya
Deletions of the Plasmodium falciparum hrp2 and hrp3 genes can affect the performance of HRP2-based malaria rapid diagnostic tests (RDTs). Such deletions have been reported from South America, India and Eritrea. ...
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Article
Open AccessCharacterizing the impact of sustained sulfadoxine/pyrimethamine use upon the Plasmodium falciparum population in Malawi
Malawi experienced prolonged use of sulfadoxine/pyrimethamine (SP) as the front-line anti-malarial drug, with early replacement of chloroquine and delayed introduction of artemisinin-based combination therapy....
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Article
Open AccessAllele-specific antibodies to Plasmodium vivax merozoite surface protein-1: prevalence and inverse relationship to haemoglobin levels during infection
Antigenic polymorphisms are considered as one of the main strategies employed by malaria parasites to escape from the host immune responses after infections. Merozoite surface protein-1 (MSP-1) of Plasmodium viva...
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Article
Biochemical and ecophysiological responses to manganese stress by ectomycorrhizal fungus Pisolithus tinctorius and in association with Eucalyptus grandis
At relatively low concentrations, the element manganese (Mn) is essential for plant metabolism, especially for photosynthesis and as an enzyme antioxidant cofactor. However, industrial and agricultural activit...
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Article
Open AccessSample size and power calculations for detecting changes in malaria transmission using antibody seroconversion rate
Several studies have highlighted the use of serological data in detecting a reduction in malaria transmission intensity. These studies have typically used serology as an adjunct measure and no formal examinati...
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Article
Open AccessSerology describes a profile of declining malaria transmission in Farafenni, The Gambia
Malaria morbidity and mortality has declined in recent years in a number of settings. The ability to describe changes in malaria transmission associated with these declines is important in terms of assessing t...
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Article
Open AccessSample size determination for estimating antibody seroconversion rate under stable malaria transmission intensity
In the last decade, several epidemiological studies have demonstrated the potential of using seroprevalence (SP) and seroconversion rate (SCR) as informative indicators of malaria burden in low transmission se...
