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Open AccessAuthor Correction: Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations
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Article
Open AccessWhole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations
Circulating metabolite levels may reflect the state of the human organism in health and disease, however, the genetic architecture of metabolites is not fully understood. We have performed a whole-genome seque...
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Article
Open AccessA multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood
In a multi-stage analysis of 52,436 individuals aged 17-90 across diverse cohorts and biobanks, we train, test, and evaluate a polygenic risk score (PRS) for hypertension risk and progression. The PRS is train...
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Article
Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
A Correction to this paper has been published: https://doi.org/10.1038/s41588-021-00832-z.
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Article
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to ~1.3 million participants, we discovered 106 new BP-associated g...
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Article
Open AccessWhole genome sequence analysis of serum amino acid levels
Blood levels of amino acids are important biomarkers of disease and are influenced by synthesis, protein degradation, and gene–environment interactions. Whole genome sequence analysis of amino acid levels may ...
