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Article
Open AccessClinical risk factors and cancer risk of thyroid imaging reporting and data system category 4 A thyroid nodules
Beyond the Thyroid Imaging Reporting and Data System (TIRADS) classification of thyroid nodules, additional factors must be weighed in the decision to perform fine needle aspiration (FNA). In this study, we ai...
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Article
Open AccessAssessing the impact of type 2 diabetes on mortality and life expectancy according to the number of risk factor targets achieved: an observational study
Type 2 diabetes (T2D) is associated with an increased risk of premature death. Whether multifactorial risk factor modification could attenuate T2D-related excess risk of death is unclear. We aimed to examine t...
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Article
Open AccessSGLT2 inhibition, circulating metabolites, and atrial fibrillation: a Mendelian randomization study
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have shown promise in reducing the risk of atrial fibrillation (AF). However, the results are controversial and the underlying metabolic mechanism remains uncl...
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Article
Investigating the shared genetic architecture between schizophrenia and body mass index
Evidence for reciprocal comorbidity of schizophrenia (SCZ) and body mass index (BMI) has grown in recent years. However, little is known regarding the shared genetic architecture or causality underlying the ph...
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Article
Blood Lead Level Is Associated with Visceral Adipose Dysfunction in Patients with Type 2 Diabetes
We aimed to explore whether an elevated blood lead level (BLL) is associated with visceral adipose dysfunction in patients with type 2 diabetes mellitus (T2DM). Four thousand one hundred and fourteen diabetic ...
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Article
Open AccessHigh prevalence of metabolic diseases, liver steatosis and fibrosis among Chinese psychiatric patients
We aimed to investigate the differences of metabolic disorders between the general population and psychiatric patients, with an emphasis on the prevalence and influencing factors of liver fibrosis in psychiatr...
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Article
Open AccessAssociation of accelerometer-derived circadian abnormalities and genetic risk with incidence of atrial fibrillation
Evidence suggests potential links between circadian rhythm and atrial fibrillation (AF). However, whether circadian disruption can predict the onset of AF in the general population remains largely unknown. We ...
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Article
Open AccessAssociation between sleep duration and metabolic syndrome: linear and nonlinear Mendelian randomization analyses
Observational studies have found that both short and long sleep duration are associated with increased risk of metabolic syndrome (MetS). This study aimed to examine the associations of genetically determined ...
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Article
Open AccessThe associations of total testosterone with probable nonalcoholic steatohepatitis and nonalcoholic fatty liver disease fibrotic progression in men with type 2 diabetes: a cross-sectional study
Testosterone has an impact on metabolic disorders and men with type 2 diabetes mellitus (T2DM) are predisposed to hypogonadism; meanwhile, patients with T2DM have higher risk of NAFLD. Therefore, we speculate ...
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Article
Exposure to phthalates and cardiovascular diseases in Chinese with type 2 diabetes
Cardiovascular disease (CVD) results in more than half of the mortality and the majority of morbidity in patients with type 2 diabetes. We aim to evaluate the associations of urinary concentrations of phthalat...
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Article
Blood lead, nutrient intake, and renal function among type 2 diabetic patients
Lead (Pb) exposure has been reported to have nephrotoxicity. However, such an effect has not been well investigated in type 2 diabetes (T2D) patients, especially when taking into account the nutrition status o...
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Article
Early-life exposure to the Chinese famine, genetic susceptibility and the risk of type 2 diabetes in adulthood
Early famine exposure has been related to the development of type 2 diabetes; however, little is known about whether the genetic background modifies this association. We aimed to investigate the joint effects ...
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Article
Open AccessIodine nutrition status and its association with microvascular complications in urban dwellers with type 2 diabetes
The principal function of iodine acts on thyroid function, but in recent years, the role of iodine deficiency in metabolism has also been gradually revealed. We aimed to investigate the current status of iodiz...
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Article
Open AccessAssociations between abdominal obesity indices and diabetic complications: Chinese visceral adiposity index and neck circumference
Obesity, especially abdominal obesity, has been considered a risk factor for diabetic complications. Many abdominal obesity indices have been established, including neck circumference (NC), waist-to-hip ratio ...
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Article
Open AccessThe unique association between the level of peripheral blood monocytes and the prevalence of diabetic retinopathy: a cross-sectional study
The attraction and influx of monocytes into the retina has been considered a critical step in the development of diabetic retinopathy (DR). However, large population studies about the association between perip...
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Article
Open AccessAssociation between famine exposure in early life with insulin resistance and beta cell dysfunction in adulthood
Famine exposure in early life was associated with type 2 diabetes, non-alcoholic fatty liver disease and metabolic syndrome, etc. But evidence in early famine exposure and insulin resistance and beta cell dysf...
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Article
Open AccessAssociation between serum vitamin D and uric acid in the eastern Chinese population: a population-based cross-sectional study
Uric acid (UA) is the end product of purine metabolism, which is thought to be related to many human diseases, such as nephrolithiasis, gout, cardiovascular disease (CVD), type 2 diabetes mellitus, metabolic s...
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Article
Vitamin D, prediabetes and type 2 diabetes: bidirectional Mendelian randomization analysis
Vitamin D deficiency is associated with glycemic dysregulation in many observational studies. However, the causality between them has not been fully established, especially in Asian origin. We used bidirection...
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Article
Open AccessAssociation of 25-hydroxyvitamin D with cardiometabolic risk factors and metabolic syndrome: a mendelian randomization study
Low circulating vitamin D levels have been associated with increased risk of metabolic syndrome (MS) and cardiometabolic risk factors in multiple epidemiology studies. However, whether this association is caus...
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Article
Open AccessNovel associations between sex hormones and diabetic vascular complications in men and postmenopausal women: a cross-sectional study
Associations between sex hormones and vascular remodeling have been extensively studied, but the results vary widely among different races and sex. We aimed to investigate whether total testosterone (TT), estr...
