7 Result(s)
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Mentoring the next generation of cell biologists
As Nature Cell Biology turns 25 years old, we asked cell biologists across the globe to share their thoughts on what a productive mentor–mentee relationship looks like and their views on training the next generat...
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Open AccessHyaluronic acid–GPRC5C signalling promotes dormancy in haematopoietic stem cells
Bone marrow haematopoietic stem cells (HSCs) are vital for lifelong maintenance of healthy haematopoiesis. In inbred mice housed in gnotobiotic facilities, the top of the haematopoietic hierarchy is occupied b...
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Open AccessPublisher Correction: Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration
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Open AccessChemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration
Haematopoietic stem cells (HSCs) are normally quiescent, but have evolved mechanisms to respond to stress. Here, we evaluate haematopoietic regeneration induced by chemotherapy. We detect robust chromatin reor...
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Haematopoietic stem cells in perisinusoidal niches are protected from ageing
With ageing, intrinsic haematopoietic stem cell (HSC) activity decreases, resulting in impaired tissue homeostasis, reduced engraftment following transplantation and increased susceptibility to diseases. Howev...
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Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis
The dynamics of haematopoietic stem cell differentiation and the hierarchy of oligopotent stem cells in the bone marrow remain controversial. Here we dissect haematopoietic progenitor populations at single cel...
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Open AccessTetracycline-controlled transgene activation using the ROSA26-iM2-GFP knock-in mouse strain permits GFP monitoring of DOX-regulated transgene-expression
Conditional gene activation is an efficient strategy for studying gene function in genetically modified animals. Among the presently available gene switches, the tetracycline-regulated system has attracted con...
