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The human Werner Syndrome as a model system for aging
The aging process is one of the most challenging biological pathways to understand. Applications of model systems for aging have contributed...
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Aging and mitochondrial dysfunction in the filamentous fungus Podospora anserina
In the filamentous fungus Podospora anserina, mitochondria play a paramount role in life span control and aging. During aging, these organelles...
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Aging and the programmed death phenomena
Biochemical mechanisms of the programmed death phenomena are considered at levels of unicellular organisms, mitochondria, cells, groups of cells, and...
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Conditional senescence in prokaryotes
Bacteria are immortal in the sense that their capacity for reproduction appears limitless as long as the environment supports growth. However, this...
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Do green plants age, and if so, how?
Time-dependent ageing-like processes in green plants are discussed and compared to gerontological changes in animals and other organisms. The...
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Energy metabolism, anti-oxidant defense and aging in Caenorhabditis elegans
Food restriction and impaired gene function by mutation or RNAi treatment can extend the lifespan of Caenorhabditis elegans considerably. In contrast...
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Yeast as a model for ageing and apoptosis research
Apoptosis is a form of programmed cell death with a crucial role in health and disease in metazoans. Recent findings demonstrate the existence of an...
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Mammalian and bird aging, oxygen radicals, and restricted feeding
In this chapter, the relationship of aging with oxidative stress is reviewed. Endogenous tissue antioxidants do not determine aging because they...
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Role of subcytotoxic stress in tissue ageing
Most commonly stress-induced premature senescence (SIPS) is defined as the long-term effects of subcytotoxic stress on proliferative cell types,...
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Mitochondria, metabolism, and aging in yeast
Quantitative and qualitative changes in metabolism take place when the lifespan is extended in yeast either by genetic or nutritional manipulation....
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Plasma metabolites in childhood Burkitt lymphoma cases and cancer-free controls in Uganda
IntroductionBurkitt lymphoma (BL) is an aggressive non-Hodgkin lymphoma associated with Plasmodium falciparum and Epstein-Barr virus, both of which...
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Designing optimal experiments in metabolomics
BackgroundMetabolomics data is often complex due to the high number of metabolites, chemical diversity, and dependence on sample preparation. This...
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Analyzing the impact of T7L variants overexpression on the metabolic profile of Escherichia coli
IntroductionExploring metabolic changes within host E. coli through an untargeted metabolomic study of T7L variants overexpression to optimize...
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Introduced mice influence the large-bodied alpine invertebrate community
Invasive mammalian predators are a key threat to native fauna globally. Island ecosystems that developed in isolation from mammals are particularly...
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An alternative approach of TUNEL assay to specifically characterize DNA fragmentation in cell model systems
DNA damage is one of the most important effects induced by chemical agents. We report a comparative analysis of DNA fragmentation on three different...
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Morphology of cuticular structures in the ant genus Strumigenys (Insecta: Hymenoptera: Formicidae)
Ants in the genus Strumigenys have an assortment of structures that appear to hold environmental debris that acts as camouflage to facilitate their...
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Digging into boring bryozoans: new characters and new species of Immergentiidae
Immergentia is an endolithic genus of ctenostome bryozoans and the sole member of the Immergentiidae. Etchings of their typical spindled-shaped and...
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Decellularized leaf-based biomaterial supports osteogenic differentiation of dental pulp mesenchymal stem cells
Decellularized tissues are an attractive scaffolds for 3D tissue engineering. Decellularized animal tissues have certain limitations such as the...
