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Article
A diffusible small-RNA-based Turing system dynamically coordinates organ polarity
The formation of a flat and thin leaf presents a developmentally challenging problem, requiring intricate regulation of adaxial–abaxial (top–bottom) polarity. The patterning principles controlling the spatial ...
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Chapter and Conference Paper
Structure-Preserving Multi-domain Stain Color Augmentation Using Style-Transfer with Disentangled Representations
In digital pathology, different staining procedures and scanners cause substantial color variations in whole-slide images (WSIs), especially across different laboratories. These color shifts result in a poor g...
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Article
Haematopoietic stem cells in perisinusoidal niches are protected from ageing
With ageing, intrinsic haematopoietic stem cell (HSC) activity decreases, resulting in impaired tissue homeostasis, reduced engraftment following transplantation and increased susceptibility to diseases. Howev...
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Article
Open AccessAutomated detection of the HER2 gene amplification status in Fluorescence in situ hybridization images for the diagnostics of cancer tissues
The human epidermal growth factor receptor 2 (HER2) gene amplification status is a crucial marker for evaluating clinical therapies of breast or gastric cancer. We propose a deep learning-based pipeline for th...
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Protocol
Statistical and Mathematical Modeling of Spatiotemporal Dynamics of Stem Cells
Statistical and mathematical modeling are crucial to describe, interpret, compare, and predict the behavior of complex biological systems including the organization of hematopoietic stem and progenitor cells i...
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Chapter and Conference Paper
Combining Deep Learning and Active Contours Opens The Way to Robust, Automated Analysis of Brain Cytoarchitectonics
Deep learning has thoroughly changed the field of image analysis yielding impressive results whenever enough annotated data can be gathered. While partial annotation can be very fast, manual segmentation of 3D...
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Article
Open AccessTransdifferentiation of pancreatic cells by loss of contact-mediated signaling
Replacement of dysfunctional β-cells in the islets of Langerhans by transdifferentiation of pancreatic acinar cells has been proposed as a regenerative therapy for diabetes. Adult acinar cells spontaneously rever...
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Reference Work Entry In depth
Cellular Potts Model
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Chapter and Conference Paper
Complex System Simulations with QosCosGrid
The aim of the QosCosGrid project is to bring supercomputer-like performance and structure to cross-cluster computations. To support parallel complex systems simulations, QosCosGrid provides six reusable templ...
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Chapter and Conference Paper
Niche Differentiation and Coexistence in a Multi-resource Ecosystem with Competition
As a step towards modeling the evolution of food webs from an individual-based perspective, here we study the evolutionary dynamics of a simple multi-resource ecosystem model at the basal level of a food web. ...
