-
Article
Addition of α-synuclein aggregates to the intestinal environment recapitulates Parkinsonian symptoms in model systems
The gut-brain axis plays a vital role in Parkinson’s disease (PD). The mechanisms of gut-brain transmission mainly focus on α-synuclein deposition, intestinal inflammation and microbiota function. A few studie...
-
Article
Pharmacological characterization of the small molecule 03A10 as an inhibitor of α-synuclein aggregation for Parkinson’s disease treatment
Aggregation of α-synuclein, a component of Lewy bodies (LBs) or Lewy neurites in Parkinson’s disease (PD), is strongly linked with disease development, making it an attractive therapeutic target. Inhibiting ag...
-
Article
Natural product 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose is a reversible inhibitor of glyceraldehyde 3-phosphate dehydrogenase
Aerobic glycolysis, also known as the Warburg effect, is a hallmark of cancer cell glucose metabolism and plays a crucial role in the activation of various types of immune cells. Glyceraldehyde 3-phosphate deh...
-
Article
Pharmacokinetics-based identification of pseudoaldosterogenic compounds originating from Glycyrrhiza uralensis roots (Gancao) after dosing LianhuaQingwen capsule
LianhuaQingwen capsule, prepared from an herbal combination, is officially recommended as treatment for COVID-19 in China. Of the serial pharmacokinetic investigations we designed to facilitate identifying Lia...
-
Article
Correction to: Protective Effects of 28-O-Cafeoyl Betulin (B-CA) on the Cerebral Cortex of Ischemic Rats Revealed by a NMR-Based Metabolomics Analysis
In the original version of this article, unfortunately the Fig. 3C and 3F were published with incorrect version. The correct version of the Fig. 3C and 3F are given below. This has been corrected by publishing...
-
Article
Protective Effects of 28-O-Caffeoyl Betulin (B-CA) on the Cerebral Cortex of Ischemic Rats Revealed by a NMR-Based Metabolomics Analysis
28-O-caffeoyl betulin (B-CA) has been demonstrated to reduce the cerebral infarct volume caused by transient middle cerebral artery occlusion (MCAO) injury. B-CA is a novel derivative of naturally occurring caffe...
-
Article
Interplay between Alzheimer’s disease and global glucose metabolism revealed by the metabolic profile alterations of pancreatic tissue and serum in APP/PS1 transgenic mice
Increasing evidence suggests that there is a correlation between type 2 diabetes mellitus (T2D) and Alzheimer’s disease (AD). Increased Aβ polypeptide production in AD patients would promote metabolic abnormal...
-
Article
NMR-based platform for fragment-based lead discovery used in screening BRD4-targeted compounds
Fragment-based lead discovery (FBLD) is a complementary approach in drug research and development. In this study, we established an NMR-based FBLD platform that was used to screen novel scaffolds targeting hum...
-
Article
Cordyceps sinensis protects against liver and heart injuries in a rat model of chronic kidney disease: a metabolomic analysis
To test the hypothesis that the traditional Chinese medicine Cordyceps sinensis could improve the metabolic function of extrarenal organs to achieve its anti-chronic kidney disease (CKD) effects.
