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Article
Atomistic study on the microscopic mechanism of grain boundary embrittlement induced by small dense helium bubbles in iron
The helium bubbles induced by 14 MeV neutron irradiation can cause intergranular fractures in reduced activation ferritic martensitic steel, which is a candidate structural material for fusion reactors. In ord...
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Article
Grain boundary engineering for enhancing intergranular damage resistance of ferritic/martensitic steel P92
Ferritic/martensitic (F/M) steel is widely used as a structural material in thermal and nuclear power plants. However, it is susceptible to intergranular damage, which is a critical issue, under service condit...
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Article
Addition of α-synuclein aggregates to the intestinal environment recapitulates Parkinsonian symptoms in model systems
The gut-brain axis plays a vital role in Parkinson’s disease (PD). The mechanisms of gut-brain transmission mainly focus on α-synuclein deposition, intestinal inflammation and microbiota function. A few studie...
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Article
Open AccessSingle-cell genomic variation induced by mutational processes in cancer
How cell-to-cell copy number alterations that underpin genomic instability1 in human cancers drive genomic and phenotypic variation, and consequently the evolution of cancer2, remains understudied. Here, by apply...
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Article
A highly efficient humidity sensor based on lead (II) coordination polymer via in-situ decarboxylation and hydrolysis synthesis
Function-oriented design of coordination polymers is emerging as an attracting topic to explore their practical applications, e.g., gas/humidity sensing. However, the successful synthesis of new coordination p...
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Article
Epac activation ameliorates tubulointerstitial inflammation in diabetic nephropathy
Tubulointerstitial inflammation plays an important role in the progression of diabetic nephropathy (DN), and tubular epithelial cells (TECs) are crucial promoters of the inflammatory cascade. Exchange protein ...
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Article
Paeoniflorin ameliorates ischemic injury in rat brain via inhibiting cytochrome c/caspase3/HDAC4 pathway
Paeoniflorin (PF), a bioactive monoterpene glucoside, has shown a variety of pharmacological effects such as anti-inflammation and autophagy modulation etc. In this study, we investigated whether and how PF ex...
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Article
Open AccessGenomic evidence of prevalent hybridization throughout the evolutionary history of the fig-wasp pollination mutualism
Ficus (figs) and their agaonid wasp pollinators present an ecologically important mutualism that also provides a rich comparative system for studying functional co-diversification throughout its coevolutionary hi...
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Article
Open AccessBDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer
3-Hydroxy butyrate dehydrogenase 2 (BDH2) is a short-chain dehydrogenase/reductase family member that plays a key role in the development and pathogenesis of human cancers. However, the role of BDH2 in gastric...
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Article
Microstructure quantification of Cu–4.7Sn alloys prepared by two-phase zone continuous casting and a BP artificial neural network model for microstructure prediction
Microstructures of Cu–4.7Sn (%) alloys prepared by two-phase zone continuous casting (TZCC) technology contain large columnar grains and small grains. A compound grain structure, composed of a large columnar g...
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Article
The value of serum RASSF10 hypermethylation as a diagnostic and prognostic tool for gastric cancer
The tumor-suppressing role of Ras-association domain family 10 (RASSF10) has been described in several types of cancers. Here, we evaluated the potential use of the hypermethylation status of the RASSF10 promoter...
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Article
Low expression of fibulin-1 correlates with unfavorable prognosis in gastric cancer
The tumor-suppressing role of fibulin-1 has been described in several types of cancers. However, the expression and role of fibulin-1 in the development and progression of gastric cancer (GC) remain largely un...
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Article
Open AccessAsialoglycoprotein receptor-magnetic dual targeting nanoparticles for delivery of RASSF1A to hepatocellular carcinoma
We developed a nanovector with double targeting properties for efficiently delivering the tumor suppressor gene RASSF1A specifically into hepatocellular carcinoma (HCC) cells by preparing galactosylated-carbox...
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Article
Isolation and characterization of polymorphic microsatellite markers in Schisandra chinensis (Turcz.) Baill. (Schisandraceae)
Fourteen polymorphic microsatellite markers were developed and characterized in Schisandra chinensis, a widely used traditional Chinese herbal medicine. The average number of alleles of these microsatellites was ...
