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Article
Locomotor improvement of spinal cord-injured rats through treadmill training by forced plantar placement of hind paws
Experimental training model of rats with spinal cord injury (SCI).
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Article
Open AccessPlasma microRNA profiles: identification of miR-25 as a novel diagnostic and monitoring biomarker in oesophageal squamous cell carcinoma
Recent studies have demonstrated that microRNAs are stably detectable in plasma/serum because of their binding to specific proteins or being packaged in secretory particles. This study was designed to detect n...
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Article
The Effect of Changing Positive End-Expiratory Pressures on the Spatial Pattern of Lung Ventilation in Newborn Rabbits Ventilated from Birth
Background: Positive end-expiratory pressure (PEEP) helps very preterm newborns develop functional residual capacity (FRC) and establish adequate gas exchange at birth. In the immediate newborn period, lungs comm...
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Chapter and Conference Paper
Optimising Coherence Properties for Phase Contrast X-Ray Imaging (PCXI) to Reveal Airway Surface Liquid (ASL) as an Airway Health Measure
We demonstrate the potential of PCXI in achieving a non-invasive measure of airway health, for the assessment of new therapies for cystic fibrosis (CF). In particular, the advantages to an increased transverse...
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Chapter and Conference Paper
Increasing Preload Reduced Actin-Myosin Interaction in Isolated Beating Rat Whole Heart Under Hypoxia
Background: Hypoxia reduces cardiac contractile performance. However, there is no direct observation on how preload affects the actinmyosin-interaction (AMI) in beating hearts during hypoxia. Purpose: The aim ...
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Article
A vertebrobasilar junction aneurysm associated with fenestration treated by intra-aneurysmal embolization
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Article
Effects of inorganic phosphate on cross-bridge behavior after photorelease of ATP in permeabilized cells of rat skeletal muscle
Effects of 20 mM inorganic phosphate on the cross-bridge behavior after photorelease of ATP from caged ATP was studied by X-ray diffraction in rat skinned psoas muscle fibers at 16°C. In the first 30 ms after...
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Article
Single turnover of cross-bridge ATPase in rat muscle fibers studied by photolysis of caged ATP
A mechanical study on skinned rat psoas muscle fibers was performed at about 16°C with X-ray diffraction and caged-ATP photolysis. The amount of photoreleased ATP was set <0.2 mM for analysis of a `single turn...
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Article
Structural changes in myosin cross-bridges during shortening of frog skeletal muscle
X-ray diffraction patterns from frog sartorius muscle were recorded during steady shortening with various loads. The intensity of the third meridional reflection from the thick filament decreased on shortening...
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Article
X-ray diffraction study on mammalian visceral smooth muscles in resting and activated states
Structural changes of guinea pig taenia coli and rat anococcygeus muscle during contraction were studied by X-ray diffraction. The diffraction pattern of the taenia coli showed the 14.4-nm myosin reflection, t...
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Chapter
Current X-Ray Diffraction Experiments using a Synchrotron Radiation Source
A Fuji imaging plate and synchrotron radiation are the most distinct innovations of the last twenty years in the X-ray diffraction experiments on biological materials. Here we present results of recent experim...
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Article
Effects of N-ethylmaleimide on the structure of skinned frog skeletal muscles
The effects of N-ethylmaleimide (NEM) and other sulfhydryl modifiers on the structure of skinned frog skeletal muscles were studied using the X-ray diffraction technique. In sartorius muscle with full overlap ...
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Article
Effects of 2,3-butanedione monoxime on contraction of frog skeletal muscles: An X-ray diffraction study
We studied the effects of BDM (2,3-butanedione monoxime) on the tetanic contraction of frog skeletal muscles using an X-ray diffraction technique. BDM significantly increased the resting equatorial intensity r...
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Article
An X-ray diffraction study ofα-tropomyosin magnesium tactoid
The structure of the needle-shaped aggregate ofα-tropomyosin formed in the presence of Mg2+ ions (the Mg-tactoid) was studied by X-ray diffraction. Orientated specimens were prepared by magnetic orientation. The ...
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Article
Intensification of the 5.9-nm actin layer line in contracting muscle
According to the cross-bridge model1–3 of muscle contraction, an interaction of myosin heads with interdigitating actin filaments produces tension. Although X-ray equatorial diffraction patterns of active (contra...
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Chapter
Lateral Shrinkage of the Myofilament Lattice in Chemically Skinned Muscles during Contraction
A toe muscle was isolated from a hind limb of the mouse and treated with saponin to make the sarcolemma more permeable to the solutes of the bathing medium. The equatorial X-ray diffraction pattern was recorde...
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Article
Effects of glycerol on sodium and potassium concentrations in guinea pig perilymph
Blutserum, Liquor cerebrospinalis und Perilymphe von Scala vestibuli und Scala tympani wurden von 85 normalen Meerschweinchen vor und nach i.v. Glycerolapplikation entnommen und die Na- und K-Konzentration bes...
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Article
Movement of myosin heads during a heart beat
X-RAY diffraction studies of heart muscle undergoing cyclic contractions have shown that the myosin heads are transferred from the vicinity of the thick filaments to that of the thin filaments as the muscle pa...
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Article
Behaviour of myosin projections during the staircase phenomenon of heart muscle
PEAK tension of an excised heart muscle increases with the frequency of contraction1. This ‘staircase’ phenomenon has been attributed to changes in the distribution of Ca ions; it has been proposed that the sarco...
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Article
Equatorial X-ray reflections from contracting muscle after an applied stretch
The equatorial X-ray reflections were recorded from contracting muscle after a slow stretch. The intensity ratio of the 1,0 to the 1,1 reflections (I10/I11) after the stretch was not significantly different from ...