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Article
Erweiterte Spenderkriterien der Bundesärztekammer
Die Expansion des Spenderpools durch die Verwendung von Spenderorganen, die erweiterte Spenderkriterien erfüllen, verringert die Wartelistenmortalität mit einem erhöhten Risiko für das Patienten- und Transplan...
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Article
Das hepatopulmonale Syndrom
The hepatopulmonary syndrome (HPS) is a functional process and is characterized by liver cirrhosis, intrapulmonary vascular dilatation and arterial hypoxemia (paO2<70 mmHg) in the absence of a disease of the lung...
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Chapter and Conference Paper
Biohybrider Leberersatz — Einsatz im Großtiermodell
A major problem in the treatment of acute liver failure is a lack of therapeutic options for increasing intracerebral pressure (ICP). This animal model shows the efficacy of a bioartificial liver support syste...
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Chapter
Application of primary hepatocyte sandwich cultures for predictive studies of drug metabolism and precarcinogen activation
Loss of cytochrome P450 content is a common feature in conventional culture systems of primary hepatocytes. In vivo each hepatocyte is exposed to an extracellular matrix (space of Disse) at two opposing basolater...
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Chapter and Conference Paper
Ersatz von Aroclor induziertem Rattenleber S9-Mix durch Sandwichkulturen primärer Hepatozyten in HGPRT Tests
Mikrosomale Präparationen (S9-Mix) werden durch Aroclor-Induktion der Rattenleber in vivo gewonnen. Das ist für das Tier eine schmerzhafte Methode und kann zu schweren Leberschäden führen. Mikrosomale Präparat...
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Article
Tacrolimus (FK 506) biotransformation in primary rat hepatocytes depends on extracellular matrix geometry
Established in vitro models for studies of hepatic drug biotransformation include the use of primary hepatocytes. In normal liver the space of Disse provides the possibility of bilateral attachment to extracel...
