Page
%P
-
Chapter
Application of primary hepatocyte sandwich cultures for predictive studies of drug metabolism and precarcinogen activation
Loss of cytochrome P450 content is a common feature in conventional culture systems of primary hepatocytes. In vivo each hepatocyte is exposed to an extracellular matrix (space of Disse) at two opposing basolater...
-
Article
Tacrolimus (FK 506) biotransformation in primary rat hepatocytes depends on extracellular matrix geometry
Established in vitro models for studies of hepatic drug biotransformation include the use of primary hepatocytes. In normal liver the space of Disse provides the possibility of bilateral attachment to extracel...
