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  1. Article

    Open Access

    Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis

    Metastasis is the most common cause of death in cancer patients. Canonical drugs target mainly the proliferative capacity of cancer cells, which leaves slow-proliferating, persistent cancer cells unaffected. M...

    Nicole Kiweler, Catherine Delbrouck, Vitaly I. Pozdeev… in Nature Communications (2022)

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  2. Article

    Open Access

    Targeting HIF-1 alpha transcriptional activity drives cytotoxic immune effector cells into melanoma and improves combination immunotherapy

    Hypoxia is a key factor responsible for the failure of therapeutic response in most solid tumors and promotes the acquisition of tumor resistance to various antitumor immune effectors. Resha** the hypoxic im...

    Audrey Lequeux, Muhammad Zaeem Noman, Malina **ao, Kris Van Moer, Meriem Hasmim… in Oncogene (2021)

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  3. No Access

    Chapter

    Hypoxia: A Formidable Saboteur of the Anti-tumor Response

    The tumor microenvironment (TME) promotes neoplastic transformation, supports tumor growth and invasion, protects the tumor from host immunity and fosters therapeutic resistance. It is well established that tu...

    Meriem Hasmim, Yosra Messai, Stéphane Terry… in Resistance of Cancer Cells to CTL-Mediated… (2015)

  4. No Access

    Article

    Crosstalk between CTC, Immune System and Hypoxic Tumor Microenvironment

    Accumulating evidence indicate that the behavior of tumorigenic cells is highly influenced by their microenvironment. In this regard, microenvironmental hypoxia plays a determinant role in the emergence of CTC...

    Muhammad Zaeem Noman, Yosra Messai, Jane Muret, Meriem Hasmim… in Cancer Microenvironment (2014)