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  1. Article

    Open Access

    The Neuropilin-1/PKC axis promotes neuroendocrine differentiation and drug resistance of prostate cancer

    Neuroendocrine prostate cancer (NEPC) is a multi-resistant variant of prostate cancer (PCa) that has become a major challenge in clinics. Understanding the neuroendocrine differentiation (NED) process at the m...

    Charly Blanc, Anissa Moktefi, Ariane Jolly… in British Journal of Cancer (2023)

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  2. No Access

    Chapter

    Hypoxia: A Formidable Saboteur of the Anti-tumor Response

    The tumor microenvironment (TME) promotes neoplastic transformation, supports tumor growth and invasion, protects the tumor from host immunity and fosters therapeutic resistance. It is well established that tu...

    Meriem Hasmim, Yosra Messai, Stéphane Terry… in Resistance of Cancer Cells to CTL-Mediated… (2015)

  3. Article

    Open Access

    Hedgehog/Gli supports androgen signaling in androgen deprived and androgen independent prostate cancer cells

    Castration resistant prostate cancer (CRPC) develops as a consequence of hormone therapies used to deplete androgens in advanced prostate cancer patients. CRPC cells are able to grow in a low androgen environm...

    Mengqian Chen, Michael A. Feuerstein, Elina Levina, Prateek S. Baghel… in Molecular Cancer (2010)

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  4. No Access

    Article

    The NF-κB/IL-6 pathway in metastatic androgen-independent prostate cancer: new therapeutic approaches?

    The nuclear factor of kappa beta (NF-κB) transcription factor regulates the transcription of numerous genes including that of interleukin 6 (IL-6). The IL-6 acts as an autocrine and paracrine growth factor of ...

    Bernard Paule, Stéphane Terry, Laurence Kheuang, Pascale Soyeux… in World Journal of Urology (2007)