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Article
Open AccessMitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis
Metastasis is the most common cause of death in cancer patients. Canonical drugs target mainly the proliferative capacity of cancer cells, which leaves slow-proliferating, persistent cancer cells unaffected. M...
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Article
Open AccessTargeting HIF-1 alpha transcriptional activity drives cytotoxic immune effector cells into melanoma and improves combination immunotherapy
Hypoxia is a key factor responsible for the failure of therapeutic response in most solid tumors and promotes the acquisition of tumor resistance to various antitumor immune effectors. Resha** the hypoxic im...
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Chapter
Hypoxia: A Formidable Saboteur of the Anti-tumor Response
The tumor microenvironment (TME) promotes neoplastic transformation, supports tumor growth and invasion, protects the tumor from host immunity and fosters therapeutic resistance. It is well established that tu...
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Article
Crosstalk between CTC, Immune System and Hypoxic Tumor Microenvironment
Accumulating evidence indicate that the behavior of tumorigenic cells is highly influenced by their microenvironment. In this regard, microenvironmental hypoxia plays a determinant role in the emergence of CTC...